机构：[1]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine (SJTU‐SM), 280 South Chongqing Road, Shanghai 200025, China[2]Department of Pharmacy, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China[3]Department of General Surgery, Shanghai Tongren Hospital, SJTU‐SM, 1111 Xianxia Road, Shanghai 200336, China
Alantolactone (ALA), a sesquiterpene lactone isolated from several medicinal plants such as Inula helenium, has been identified to have attractive anticancer activity. However, its role in the inhibition of angiogenesis during tumor development remains unclear. In this study, we found ALA can inhibit the proliferation, motility, migration, and tube formation of human umbilical vein endothelial cells. ALA also restrained angiogenesis in chick embryo chorioallantoic membrane and delayed the growth of human MDA-MB-231 breast cancer xenograft in mice through angiogenesis inhibition. Furthermore, ALA suppressed the phosphorylation of vascular endothelial growth factor receptor 2 and its downstream protein kinase including PLC1, FAK, Src, and Akt in endothelial cells. Taken together, the antiangiogenic activity of ALA and its molecular mechanism are identified for the first time, indicating that ALA may be a potential drug candidate or lead compound for antiangiogenic cancer therapy.
基金：
National Natural Science Foundation of China,
Grant/Award Numbers: 81572998 and
81602729; “Shu Guang” Program of Shanghai
Education Development Foundation and
Shanghai Municipal Education Commission,
Grant/Award Number: 16SG13
第一作者机构：[1]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine (SJTU‐SM), 280 South Chongqing Road, Shanghai 200025, China[2]Department of Pharmacy, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China
共同第一作者：
通讯作者：
通讯机构：[1]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine (SJTU‐SM), 280 South Chongqing Road, Shanghai 200025, China[2]Department of Pharmacy, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China[*1]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine (SJTU‐SM), 280 South Chongqing Road, Shanghai 200025, China.[*2]Department of Pharmacy, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China.
推荐引用方式(GB/T 7714)：
Liu Ya-Rong,Cai Qin-Yi,Gao Yun-Ge,et al.Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling[J].PHYTOTHERAPY RESEARCH.2018,32(4):643-650.doi:10.1002/ptr.6004.
APA：
Liu, Ya-Rong,Cai, Qin-Yi,Gao, Yun-Ge,Luan, Xin,Guan, Ying-Yun...&Fang, Chao.(2018).Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling.PHYTOTHERAPY RESEARCH,32,(4)
MLA：
Liu, Ya-Rong,et al."Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling".PHYTOTHERAPY RESEARCH 32..4(2018):643-650
