机构：[1]Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China[2]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University.Beijing Ophthalmology & Visual Sciences Key Laboratory.National Engineering Research Center for Ophthalmology, Beijing 100730, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China[4]Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China
Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method. Intra-ocular pressure was changed from 10 to 90 mmHg using two different loading rates to observe the pressure-apex displacement relationship and calculate the apparent stiffness of the corneas. Stiffness of the corneal phantoms obtained by the inflation test ranged from 0.2 to 1 MPa, which was highly consistent with the results from the mechanical tensile test (y = 0.70x, p < 0.001). The porcine corneas showed highly viscoelastic behavior with obvious hysteresis in inflation. The apparent stiffness of the porcine corneas was 0.63 +/- 0.07 and 1.05 +/- 0.08 MPa with loading rates of 3.3 and 33 mmHg/min, respectively. Mapping of corneal surface displacement was also generated for both the phantom and porcine corneas. This study showed that it is feasible to incorporate the high resolution OCT imaging in inflation test to measure the biomechanical properties of the cornea.
基金：
National Natural Science Foundation of China
(31600758), Beijing Natural Science Foundation
(7174287), Beijing Nova Program (xx2018076) and
Beijing Municipal Administration of Hospitals’ Youth Programme (QMS20170204).
第一作者机构：[1]Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China[*1]School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China[*2]Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
推荐引用方式(GB/T 7714)：
Wang Like,Tian Lei,Huang Yanping,et al.Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography[J].ANNALS OF BIOMEDICAL ENGINEERING.2018,46(2):247-256.doi:10.1007/s10439-017-1973-7.
APA：
Wang, Like,Tian, Lei,Huang, Yanping,Huang, Yifei&Zheng, Yongping.(2018).Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography.ANNALS OF BIOMEDICAL ENGINEERING,46,(2)
MLA：
Wang, Like,et al."Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography".ANNALS OF BIOMEDICAL ENGINEERING 46..2(2018):247-256
