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Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic β-cells

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收录情况： ◇ SCIE

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机构： [1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China [3]School of Biomedical Sciences, University of Queensland, Brisbane, QLD, 4072, Australia

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关键词： ACE2 Insulin secretion Intracellular calcium Mitochondrial metabolism Pancreatic beta-cells

摘要：

Mitochondrial metabolism plays an essential role in the regulation of insulin release and glucose homeostasis. Evidence demonstrated that the angiotensin-converting enzyme 2 (ACE2) participates in the regulation of glucose metabolism, however, its role in mitochondrial metabolism remains unclear. The purpose of our study was to determine if ACE2 can regulate mitochondrial function in pancreatic beta-cells. We found that ACE2 over-expression restored glucose-stimulated insulin secretion (GSIS) and mitochondrial membrane potential (MMP) in the presence of H2O2 in INS-1 cells. PCR array demonstrated that ACE2 over-expression up-regulated 67 mitochondria-related genes in INS-1 cells. In pancreatic islets, ACE2 ablation attenuated intracellular calcium influx with a decrease in GSIS. Ace2(-/y) mice islets exhibited impaired mitochondrial respiration and lower production of ATP, along with decreased expression of genes involved in mitochondria] oxidation. In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in GSIS. These results shed light on the potential roles of ACE2 in mitochondrial metabolism, moreover, may improve our understanding of diabetes. (C) 2017 Elsevier Inc. All rights reserved.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

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出版当年[2016]版：

Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.466 出版当年[2016版] 2.354 出版当年五年平均 2.371 出版前一年[2015版] 2.559 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China

通讯作者：

通讯机构： [1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China [*1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dong Jiao Min Xiang, Eastern District, Beijing 100730, China.

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