机构：[1]Ocean Univ China, Marine Drug & Food Inst, Qingdao 266003, Peoples R China[2]Capital Univ Med Sci, Beijing Tongren Hosp, Beijing 100730, Peoples R China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Chinese Peoples Liberat Army Gen Hosp, Beijing 100853, Peoples R China[4]Chinese PLA Gen Hosp Rocket Forces, Beijing 100088, Peoples R China
Confocal laser scanning microscopy (CLSM) was applied to detect the intracellular [Ca2+] variety of fluorescent intension, with Fluo-3/AM fluorescence loaded in SFSMC. The results show that 10 mu mol/L Lacidipine can reduce the frequence which 10 mu mol/L 5-HT induced [Ca2+] spark in SFSMC of calcium over loading to 50%, and amplitude to 50% or so. We can draw a conclusion that dihydropyridines calcium antagonists lacidipine can antagonize the release of intracellular [Ca2+] which 5-HT-induced in dose dependent manner.
第一作者机构：[1]Ocean Univ China, Marine Drug & Food Inst, Qingdao 266003, Peoples R China[2]Capital Univ Med Sci, Beijing Tongren Hosp, Beijing 100730, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang ShuMin,Guan HuaShi,Fang Yi,et al.The influence of dihydropyridines calcium antagonists on 5-HT-induced intracellular calcium signal[J].SCIENCE IN CHINA SERIES B-CHEMISTRY.2007,50(4):562-567.doi:10.1007/s11426-007-0084-y.
APA：
Wang ShuMin,Guan HuaShi,Fang Yi,Ma Ping,Sun JianZi&Liu LiHong.(2007).The influence of dihydropyridines calcium antagonists on 5-HT-induced intracellular calcium signal.SCIENCE IN CHINA SERIES B-CHEMISTRY,50,(4)
MLA：
Wang ShuMin,et al."The influence of dihydropyridines calcium antagonists on 5-HT-induced intracellular calcium signal".SCIENCE IN CHINA SERIES B-CHEMISTRY 50..4(2007):562-567
