机构：[1]Edwin Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA[2]Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA[3]Department of Neurology and Cancer Center, Massachusetts General Hospital, USA[4]Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Research of various diseases of the nervous system has shown that VEGF has direct neuroprotective effects in the central and peripheral nervous systems, and indirect effects on improving neuronal vessel perfusion which leads to nerve protection. In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function. This review aims to summarize the divergent roles of VEGF in diseases of the nervous system and the recent findings of anti-VEGF therapy in nerve damage/regeneration and function in tumors, specifically, in Neurofibromatosis type 2 associated schwannomas.
基金：
Department of Defense New Investigator AwardUnited States Department of Defense [W81XWH-16-0219]; American Cancer Society Research Scholar AwardAmerican Cancer Society [RSG-12-199]; Children's Tumor Foundation Drug Discovery Initiative; Ira Spiro Award [P01-CA080124, P50-CA165962, R01-CA129371, R01-CA208205, U01-CA 224348]; NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R35-CA197743]; Lustgarten Foundation; Ludwig Center at Harvard; National Foundation for Cancer Research; Gates FoundationBill & Melinda Gates Foundation; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01CA208205, R35CA197743, P50CA165962, U01CA224348, P01CA080124, R01CA129371] Funding Source: NIH RePORTER
第一作者机构：[1]Edwin Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
共同第一作者：
通讯作者：
通讯机构：[1]Edwin Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA[4]Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA[*1]Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.[*2]Department of Radiation Oncology, Cox-7, Massachusetts General Hospital, Boston, MA 02114, USA
推荐引用方式(GB/T 7714)：
Zhang Na,Chen Jie,Ferraro Gino B.,et al.Anti-VEGF treatment improves neurological function in tumors of the nervous system[J].EXPERIMENTAL NEUROLOGY.2018,299:326-333.doi:10.1016/j.expneurol.2017.09.008.
APA：
Zhang, Na,Chen, Jie,Ferraro, Gino B.,Wu, Limeng,Datta, Meenal...&Xu, Lei.(2018).Anti-VEGF treatment improves neurological function in tumors of the nervous system.EXPERIMENTAL NEUROLOGY,299,
MLA：
Zhang, Na,et al."Anti-VEGF treatment improves neurological function in tumors of the nervous system".EXPERIMENTAL NEUROLOGY 299.(2018):326-333
