Some reports evaluated the association between ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians. The results remained unknown. Thus, we did a meta-analysis to evaluate this association. Nine case-control studies with 4198 patients and 3699 controls were included in this meta-analysis. A significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in Caucasians (OR=1.18; 95% CI, 1.08-1.28; P=0.0002). ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians from Europe (OR=1.20; 95% CI, 1.09-1.32; P=0.0002) but not from other countries (OR=1.13; 95% CI, 0.95-1.36; P=0.17). No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males (OR=1.12; 95% CI, 0.91-1.39; P=0.28). Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk (OR=1.04; 95% CI, 0.73-1.48; P=0.84). In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.
第一作者机构：[1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Neurol, Shanghai 200336, Peoples R China
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推荐引用方式(GB/T 7714)：
Li K-L.,Chen C-Y.,Xu M.,et al.ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis[J].CELLULAR AND MOLECULAR BIOLOGY.2017,63(10):137-140.doi:10.14715/cmb/2017.63.10.22.
APA：
Li, K-L.,Chen, C-Y.,Xu, M.,Zhu, X-Q.&Yang, X-J..(2017).ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis.CELLULAR AND MOLECULAR BIOLOGY,63,(10)
MLA：
Li, K-L.,et al."ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis".CELLULAR AND MOLECULAR BIOLOGY 63..10(2017):137-140
