Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. In this review, we have focused on the DUBs regulation of stem cell fate determination. For example, we discuss deubiquitinase inhibition may lead stem cell transcription factors and CSCs-related protein degradation. Also, CSCs microenvironment is regulated by DUBs activity. Our review provides a new insight into DUBs activity by emphasizing their cellular role in regulating stem cell fate and illustrates the opportunities for the application of DUBs inhibitors in the CSC-targeted therapy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570118, 81700475]
第一作者机构：[1]Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis,Minist Educ, Hongqiao Int Inst Med,Shanghai Tongren Hosp,Sch M, Fac Basic Med,Chem Biol Div,Shanghai Univ Inst E, Shanghai 200025, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Lei Hu,Shan Huizhuang,Wu Yingli.Targeting deubiquitinating enzymes in cancer stem cells[J].CANCER CELL INTERNATIONAL.2017,17:doi:10.1186/s12935-017-0472-0.
APA：
Lei, Hu,Shan, Huizhuang&Wu, Yingli.(2017).Targeting deubiquitinating enzymes in cancer stem cells.CANCER CELL INTERNATIONAL,17,
MLA：
Lei, Hu,et al."Targeting deubiquitinating enzymes in cancer stem cells".CANCER CELL INTERNATIONAL 17.(2017)
