Study Objectives: Several studies have suggested that rhinitis contributes to the pathogenesis of obstructive sleep apnea (OSA). We aimed to investigate the prevalence and influence of allergic rhinitis (AR) and non-allergic rhinitis (NAR) on severity of OSA. Methods: Two hundred forty patients with OSA confirmed by standardized polysomnography were assessed for presence of AR and NAR, using validated questionnaires and skin prick tests. Data comparison was carried out by using chi-square test, analysis of variance, and least significant difference test. Associations between severity of OSA and rhinitis, age, sex, and body mass index were assessed with ordinal logistic regression analysis. Results: The prevalence of AR and NAR among patients with OSA was 27.1% and 28.7%, respectively, with no significant differences in the severity of rhinitis. Ordinal logistic regression analysis showed AR and NAR were not the risk factors for severity of OSA. There were significant differences of polysomnography parameters in sleep efficiency (79.7 +/- 2.0 versus 85.2 +/- 1.4 between AR and NAR; 79.7 +/- 2.0 versus 87.2 +/- 1.4 between AR and no-rhinitis) and arousal index (36.8 +/- 4.1 versus 24.7 +/- 3.5 between AR and no-rhinitis). Patients with NAR had lower average arterial oxygen saturation (91.9 +/- 0.6 versus 94.0 +/- 0.6) and minimal arterial oxygen saturation (70.6 +/- 1.7 versus 77.3 +/- 1.8), compared with subjects categorized as no-rhinitis. Conclusions: This study suggests that despite a comparatively high prevalence in patients with OSA, the presence or severity of AR or NAR does not influence the severity of OSA; however, rhinitis may significantly disturb sleep in patients with OSA.
基金：
Merck Co., Inc.Merck & Company [P05537]; program for Changjiang scholars and innovative research teamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; national natural science fundsNational Natural Science Foundation of China (NSFC) [81420108009, 81630023]; Beijing natural science foundationBeijing Natural Science Foundation [7131006]; 12th five-year science and technology support project [2014BAI07B04]; Capital health research and development program [2011-1017-06]; Beijing health bureau [2009-2-007, 2011-3-039, 2011-3-043]
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China[5]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China[*1]Beijing Inst Otolaryngol, 17 HouGouHuTong, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Zheng Ming,Wang Xiangdong,Ge Siqi,et al.Allergic and Non-Allergic Rhinitis Are Common in Obstructive Sleep Apnea but Not Associated With Disease Severity[J].JOURNAL OF CLINICAL SLEEP MEDICINE.2017,13(8):959-966.doi:10.5664/jcsm.6694.
APA：
Zheng, Ming,Wang, Xiangdong,Ge, Siqi,Gu, Ying,Ding, Xiu...&Zhang, Luo.(2017).Allergic and Non-Allergic Rhinitis Are Common in Obstructive Sleep Apnea but Not Associated With Disease Severity.JOURNAL OF CLINICAL SLEEP MEDICINE,13,(8)
MLA：
Zheng, Ming,et al."Allergic and Non-Allergic Rhinitis Are Common in Obstructive Sleep Apnea but Not Associated With Disease Severity".JOURNAL OF CLINICAL SLEEP MEDICINE 13..8(2017):959-966
