Emerging evidence shows that the Hedgehog pathway and the long noncoding RNA TUG1 play pivotal roles in cell proliferation, migration, and invasion in tumors. However, the mechanism underlying the effect of TUG1 and the Hedgehog pathway in hepatoma remains undefined. In the present study, we showed that the expression of TUG1 was negatively correlated with that of microRNA (miR)-132, and depletion of TUG1 inhibited the activation of the Hedgehog pathway in vitro and in vivo. We showed that TUG1 functions as a competing endogenous (ceRNA) by competing with miR-132 for binding to the sonic hedgehog protein in HCC, thereby suppressing the activation of Hedgehog signaling and its tumorigenic effect. These data indicate that targeting the TUG1-miR132-Hedgehog network could be a new strategy for the treatment of HCC.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672344]
第一作者机构：[1]Tongji Univ, Dept Gastroenterol, Shanghai Peoples Hosp 10, Sch Med, Shanghai 200072, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Jingjing,Zhang Qinghui,Fan Xiaoming,et al.The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma[J].ONCOTARGET.2017,8(39):65932-65945.doi:10.18632/oncotarget.19582.
APA：
Li, Jingjing,Zhang, Qinghui,Fan, Xiaoming,Mo, Wenhui,Dai, Weiqi...&Guo, Chuanyong.(2017).The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma.ONCOTARGET,8,(39)
MLA：
Li, Jingjing,et al."The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma".ONCOTARGET 8..39(2017):65932-65945
医学