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Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice

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收录情况： ◇ SCIE

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机构： [1]Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Gastroenterol, Shanghai 200072, Peoples R China [2]Nanjing Med Univ, Sch Clin Med, Shanghai Hosp 10, Dept Gastroenterol, Shanghai 200072, Peoples R China [3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Dept Gastroenterol, Shanghai 200336, Peoples R China

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关键词： Warburg effect hexokinase 2 hepatoma methyl jasmonate glycolysis

摘要：

Methyl jasmonate has recently been found to have anti-cancer activity. Methyl jasmonate detached hexokinase 2 from a voltage dependent anion channel causing a reduction in mitochondrial transmembrane potential that led to the release of cytochrome C and apoptosis inducing factor resulting in intrinsic apoptosis. Blocked adenosine triphosphate synthesis caused by mitochondrial injury hampered oxidative phosphorylation and led to cell necrosis. The results were applied to the in vivo treatment of nude mice with a satisfactory effect. Collectively, our results suggest that methyl jasmonate may be an adjuvant therapy for liver tumors due to its mechanism in cancer cells compared to that in normal cells: The major function is to inhibit glycolysis instead of changing aerobic metabolism.

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出版当年[2016]版：

大类 | 1 区

医学

小类 | 2 区细胞生物学 2 区肿瘤学

最新[2025]版：

无

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出版当年[2015]版：

Q1 CELL BIOLOGY Q1 ONCOLOGY

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无

影响因子： 0 最新[2023版] 0 最新五年平均 5.008 出版当年[2015版] 5.415 出版当年五年平均 6.359 出版前一年[2014版] 5.168 出版后一年[2016版]

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第一作者机构： [1]Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Gastroenterol, Shanghai 200072, Peoples R China

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