Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression and hepatocellular carcinoma (HCC) cell glycolysis. Aerobic glycolysis was observed in four HCC cell lines compared to the normal hepatic cells. Resveratrol sensitized aerobic glycolytic HCC cells to apoptosis, and this effect was attenuated by glycolytic inhibitors. The induction of mitochondrial apoptosis was associated with the decrease of HK2 expression by resveratrol in HCC cells. In addition, resveratrol enhanced sorafenib induced cell growth inhibition in aerobic glycolytic HCC cells. Combination treatment with both reagents inhibited the growth and promoted apoptosis of HCC-bearing mice. The reduction of HK2 by resveratrol provides a new dimension to clinical HCC therapies aimed at preventing disease progression.
基金：
National Natural
Science Foundation of China [grant number 81270515].
第一作者机构：[1]Tongji Univ, Sch Med, Dept Gastroenterol, Shanghai Peoples Hosp 10, Shanghai 200092, Peoples R China
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推荐引用方式(GB/T 7714)：
Dai Weiqi,Wang Fan,Lu Jie,et al.By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice[J].ONCOTARGET.2015,6(15):13703-13717.doi:10.18632/oncotarget.3800.
APA：
Dai, Weiqi,Wang, Fan,Lu, Jie,Xia, Yujing,He, Lei...&Guo, Chuanyong.(2015).By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.ONCOTARGET,6,(15)
MLA：
Dai, Weiqi,et al."By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice".ONCOTARGET 6..15(2015):13703-13717
