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Exendin-4 protects retinal pigment epithelial cells against oxidative stress in vitro via PI3K/Akt-STAT3 activation

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机构: [1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, 5 Jingyuan Rd, Beijing, Peoples R China [2]Beijing Inst Ophthalmol, 17 Hou Gou Lane,Chong Nei St, Beijing, Peoples R China
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关键词: Retinal pigment epithelial cells oxidative stress retinal I/R injury PI3K/Akt-STAT3

摘要:
The glucagon-like peptide 1 (GLP-1) analogue Exendin-4 (Ex-4) could perform anti-oxidative effects against oxidative damage both in vitro and in vivo. However, little was known about the direct protection of Exendin-4 on RPE cells against oxidative stress and its underlying mechanism. The present study examined the protective effects of Exendin-4 on RPE cells against H2O2 treatment in vitro and retina I/R injury in vivo. The results indicated that Ex-4 exerted protective effects under H2O2 condition on RPE cells and attenuated the oxidative stress-induced damage, as evidenced by the results of cellular viability, cytotoxicity, apoptosis and western blotting. However, the protective effects of Ex-4 were mainly abrogated by p-Akt inhibitor or p-STAT3 inhibitor. In conclusion, the Ex-4 was able to protect RPE cells from H2O2 induced oxidative damage in vitro and attenuate retinal injury from I/R in vivo, which was closely related to PI3k/Akt and p-STAT3 signaling.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
最新[2023]版:
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出版当年[2015]版:
Q4 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q4 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, 5 Jingyuan Rd, Beijing, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, 5 Jingyuan Rd, Beijing, Peoples R China [*1]Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, 5 Jingyuan Road, Shijingshan District, Beijing, People’s Republic of China
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