Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In this study, it was found that LRP1B was down-regulated in colon cancer tissues and inhibited the growth, migration and metastasis of colon cancer cells. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. Taken together, our study demonstrated the suppressive roles of LRP1B in the progression of colon cancer, implicating that restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer.
第一作者机构：[1]Department of General of Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, PR China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Zhiqiang,Sun Peng,Gao Chun,et al.Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells[J].EXPERIMENTAL CELL RESEARCH.2017,357(1):1-8.doi:10.1016/j.yexcr.2017.04.010.
APA：
Wang, Zhiqiang,Sun, Peng,Gao, Chun,Chen, Ji,Li, Jun...&Xie, Jiang.(2017).Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells.EXPERIMENTAL CELL RESEARCH,357,(1)
MLA：
Wang, Zhiqiang,et al."Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells".EXPERIMENTAL CELL RESEARCH 357..1(2017):1-8
