AIM: To detect the expression of B cell receptor signaling pathway (BCRSP) in lacrimal gland benign lymphoepithelial lesions (LGBLEL). METHODS: Gene microarray was used to compare whole-genome expression in lacrimal gland tissues from LGBLEL patients to tissues from orbital cavernous hemangioma (control tissues). Expression of BCRSP was confirmed by polymerase chain reaction (PCR) and immunohistochemistry. RESULTS: The expression of 22 genes of the BCRSP increased significantly in LGBLEL patients. PCR analysis showed that CD22, CR2, and BTK were all highly expressed in LGBLEL tissues. Immunohistochemical analysis showed that CR2 protein was present in LGBLEL, but CD22 and BTK proteins were negative. CR2, CD22, and BTK were not observed in the orbital cavernous hemangiomas with either PCR or immunohistochemistry. CONCLUSION: BCRSP might be involved in the pathogenesis of LGBLEL.
基金：
National Natural Science Fund
(No.81170875; No.81371052); Key Discipline Leading
Plan in Beijing Eye Institution (No.201512); Capital of
Clinical Characteristics and the Applied Research (No.
Z151100004015115).
第一作者机构：[1]Capital Med Univ, Beijing Ophthalmol & Vis Sci Key Lab, Beijing Tongren Hosp, Beijing Tongren Eye Ctr,Beijing Inst Ophthalmol, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Ophthalmol & Vis Sci Key Lab, Beijing Tongren Hosp, Beijing Tongren Eye Ctr,Beijing Inst Ophthalmol, Beijing 100730, Peoples R China[*1]Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology &Vision Science Key Lab, Capital Medical University, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Wang Xiao-Na,Ge Xin,Li Jing,et al.B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland[J].INTERNATIONAL JOURNAL OF OPHTHALMOLOGY.2017,10(5):665-669.doi:10.18240/ijo.2017.05.01.
APA：
Wang, Xiao-Na,Ge, Xin,Li, Jing,Liu, Xiao&Ma, Jian-Min.(2017).B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland.INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,10,(5)
MLA：
Wang, Xiao-Na,et al."B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 10..5(2017):665-669
