Purpose: The role of minimally invasive endoscopic resection (MIER) in the treatment of sinonasal malignancy is controversial. Herein, we performed a retrospective review of a large case series of sinonasal malignancy patients treated with MIER aimed at evaluating the outcomes and identifying the risk factors for recurrence. Methods: Patients with sinonasal malignancy who underwent MIER from March 2000 to May 2015 were enrolled, and their clinical data were collected. The clinical outcomes were evaluated by determining the 5-year overall survival (OS) and disease-free survival (DFS). The predictive factors for survival and potential independent risk factors for recurrence were explored. Results: A total of 120 patients were enrolled, including 62 males and 58 females. The mean follow-up period was 51.4 (95% confidence interval: 44.0-59.1) months. The most frequent histological type was mucosal malignant melanoma. The positive margin rate was 19.2% (23/ 120). Seventy-one patients had the safety anatomic plane (SAP). Age >= 50 years, nodal metastasis, and not having the SAP were found to be predictive factors for survival, and absence of SAP was found to be an independent risk factor for recurrence. Conclusion: Our study indicated that MIER is an effective and safe surgical procedure in appropriately selected patients. Tumor resection with a safety anatomic boundary is likely to lead to improved survival and decreased recurrence. However, a larger sample and longterm prospective observation are still required to establish the role of MIER in treatment of sinonasal malignancy.
基金：
Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding (number XMLX201311), the Beijing Municipal Science & Technology Commission (number Z141107002514003), and The Key Scientific Research Projects of the Guangxi Zhuang Autonomous Region Health and Family Planning Commission (number 2011116).
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100703, Peoples R China[2]Minist Educ, Beijing Inst Otorhinolaryngol, Key Lab Otorhinolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100005, Peoples R China[3]Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Otolaryngol & Head & Neck Oncol, Nanning, Guangxi Zhuang, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100703, Peoples R China[2]Minist Educ, Beijing Inst Otorhinolaryngol, Key Lab Otorhinolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100005, Peoples R China[4]Beijing Key Lab Head & Neck Mol Diagnost Pathol, Beijing, Peoples R China[*1]Department of Otolaryngology - Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaominxiang, Dongcheng, Beijing 100703, People’s Republic of China[*2]Key Laboratory of Otorhinolaryngology, Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, 1 Dongjiaominxiang, Dongcheng, Beijing 100005, People’s Republic of China
推荐引用方式(GB/T 7714)：
He Ning,Chen Xiaohong,Zhang Luo,et al.Minimally invasive endoscopic resection for the treatment of sinonasal malignancy: the outcomes and risk factors for recurrence[J].THERAPEUTICS AND CLINICAL RISK MANAGEMENT.2017,13:593-602.doi:10.2147/TCRM.S131185.
APA：
He, Ning,Chen, Xiaohong,Zhang, Luo,Chen, Xuejun,Huang, Zhigang...&Fang, Jugao.(2017).Minimally invasive endoscopic resection for the treatment of sinonasal malignancy: the outcomes and risk factors for recurrence.THERAPEUTICS AND CLINICAL RISK MANAGEMENT,13,
MLA：
He, Ning,et al."Minimally invasive endoscopic resection for the treatment of sinonasal malignancy: the outcomes and risk factors for recurrence".THERAPEUTICS AND CLINICAL RISK MANAGEMENT 13.(2017):593-602
