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Biomarker identification and pathway analysis of preeclampsia based on serum metabolomics

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机构: [1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Obstet & Gynaecol, Sch Med, 1111XianXia Rd, Shanghai 200336, Peoples R China [2]Suzhou Univ, Sch Med, Suzhou 215021, Peoples R China [3]China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
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关键词: Biomarker Metabolomics Preeclampsia

摘要:
Preeclampsia presents serious risk of both maternal and fetal morbidity and mortality. Biomarkers for the detection of preeclampsia are critical for risk assessment and targeted intervention. The goal of this study is to screen potential biomarkers for the diagnosis of preeclampsia and to illuminate the pathogenesis of preeclampsia development based on the differential expression network. Two groups of subjects, including healthy pregnant women, subjects with preeclampsia, were recruited for this study. The metabolic profiles of all of the subjects' serum were obtained by liquid chromatography quadruple time of -flight mass spectrometry. Correlation between metabolites was analyzed by bioinformatics technique. Results showed that the PC(14:0/00), proline betaine and proline were potential sensitive and specific biomarkers for preeclampsia diagnosis and prognosis. Perturbation of corresponding biological pathways, such as iNOS signaling, nitric oxide signaling in the cardiovascular system, mitochondrial dysfunction were responsible for the pathogenesis of preeclampsia. This study indicated that the metabolic profiling had a good clinical significance in the diagnosis of preeclampsia as well as in the study of its pathogenesis. (C) 2017 Elsevier Inc. All rights reserved.

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出版当年[2016]版:
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版:
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
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出版当年[2015]版:
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版:
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Obstet & Gynaecol, Sch Med, 1111XianXia Rd, Shanghai 200336, Peoples R China [2]Suzhou Univ, Sch Med, Suzhou 215021, Peoples R China
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