Purpose: To study the retinal oxygen saturation in normal eyes of Chinese adolescents. Methods: Performing retinal oximetry with the Oxymap T1 Retinal Oximeter in healthy children and adolescents (aged 5-18 years old), we measured the arterial (SaO(2)) and venular (SvO(2)) oxygen saturation and the arteriovenous difference in oxygen saturation (Sa-vO(2)). Results: The study included 122 individuals with a mean age of 13.0 +/- 2.9 years (range: 5-18 years) and a mean refractive error of -3.25 +/- 2.49 dioptres (range: -8.88 to +3.13 dioptres). Mean SaO(2), SvO(2) and Sa-vO(2) was 85.5 +/- 7.1%, 48.2 +/- 5.5% and 37.3 +/- 6.5%, respectively. Mean SaO2 was significantly (p < 0.001) the lowest in the inferotemporal quadrant (79.1 +/- 9.0%), followed by the superotemporal quadrant (83.4 +/- 9.7%), the inferonasal quadrant (90.4 +/- 10.6%) and the superonasal quadrant (93.4 +/- 10.8%). In a similar manner, the values of the SvO(2) were the lowest (p < 0.001) in the inferotemporal quadrant (42.1 +/- 8.3%), followed by the superotemporal quadrant (47.8 +/- 7.2%), the inferonasal quadrant (52.3 +/- 8.4%) and the superonasal quadrant (55.1 +/- 7.6%). Arteriovenous difference in oxygen saturation (Sa-vO(2)) did not differ significantly (all p > 0.05) between the fundus quadrants. In multiple linear regression analysis, SaO(2) increased (regression coefficient r (2) = 0.28) with older age (standardized regression coefficient b: 0.23; p = 0.01) and more myopic refractive error (b: -0.39; p < 0.001). Higher SvO(2) was significantly correlated with more myopic refractive error (beta: 0.46; p < 0.001; r(2) = 0.20), while Sa-vO(2) increased significantly only with older age in the multivariate analysis (beta: 0.26; p = 0.01; r(2) = 0.07). Conclusions: Our study provides normative data for Chinese children and adolescents who showed lower values than adults for SaO(2) and SvO(2). SaO(2) increased with older age and higher myopic refractive error, SvO(2) increased with higher myopic refractive error, and Sa-vO(2) increased with older age.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7152028]
第一作者机构：[1]Capital Med Univ, Beijing Inst Ophthalmol,Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Inst Ophthalmol,Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China[*1]Beijing Inst Ophthalmol, 17 Hougou Lane, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Xue,Wang Shuang,Liu Yi,et al.Retinal oxygen saturation in Chinese adolescents[J].ACTA OPHTHALMOLOGICA.2017,95(1):E54-E61.doi:10.1111/aos.13167.
APA：
Liu, Xue,Wang, Shuang,Liu, Yi,Liu, Li Juan,Lv, Yan Yun...&Xu, Liang.(2017).Retinal oxygen saturation in Chinese adolescents.ACTA OPHTHALMOLOGICA,95,(1)
MLA：
Liu, Xue,et al."Retinal oxygen saturation in Chinese adolescents".ACTA OPHTHALMOLOGICA 95..1(2017):E54-E61
