机构：[1]School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China[2]Shanghai Children's Medical Center, Shanghai 200127, PR China[3]School of Environmental Science & Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China[4]Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing 100191, China[5]Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA[6]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine (or Faculty of Public Health), Shanghai Jiao Tong University School of Medicine[7]MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are common persistent organic pollutants (POPS) that may be associated with childhood asthma. The concentrations of PBDEs, PCBs and OCPs were analyzed in pooled serum samples from both asthmatic and non-asthmatic children. The differences in the internal exposure levels between the case and control groups were tested (p value <0.0012). The associations between the internal exposure concentrations of the POPs and childhood asthma were estimated based on the odds ratios (ORs) calculated using logistic regression models. There were significant differences in three PBDEs, 26 PCBs and seven OCPs between the two groups, with significantly higher levels in the cases. The multiple logistic regression models demonstrated that the internal exposure concentrations of a number of the POPs (23 PCBs, p,p'-DDE and alpha-HCH) were positively associated with childhood asthma. Some synergistic effects were observed when the children were co-exposed to the chemicals. BDE-209 was positively associated with asthma aggravation. This study indicates the potential relationships between the internal exposure concentrations of particular POPs and the development of childhood asthma. (C) 2015 Elsevier Inc. All rights reserved.
基金：
Shanghai Municipal Education CommissionShanghai Municipal Education Commission (SHMEC) [14YZ043]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|2 区环境科学与生态学
小类|2 区环境科学2 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|2 区环境科学与生态学
小类|2 区环境科学2 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2014]版：
Q1ENVIRONMENTAL SCIENCESQ1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q1ENVIRONMENTAL SCIENCESQ1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China
通讯作者：
通讯机构：[1]School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China[6]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine (or Faculty of Public Health), Shanghai Jiao Tong University School of Medicine[7]MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
推荐引用方式(GB/T 7714)：
Meng Ge,Feng Yan,Nie Zhiqing,et al.Internal exposure levels of typical POPs and their associations with childhood asthma in Shanghai, China[J].ENVIRONMENTAL RESEARCH.2016,146:125-135.doi:10.1016/j.envres.2015.12.026.
APA：
Meng, Ge,Feng, Yan,Nie, Zhiqing,Wu, Xiaomeng,Wei, Hongying...&Wang, Yan.(2016).Internal exposure levels of typical POPs and their associations with childhood asthma in Shanghai, China.ENVIRONMENTAL RESEARCH,146,
MLA：
Meng, Ge,et al."Internal exposure levels of typical POPs and their associations with childhood asthma in Shanghai, China".ENVIRONMENTAL RESEARCH 146.(2016):125-135
