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Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China [2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China [3]Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Hong Kong, Peoples R China [4]Univ Hong Kong, Dept Anat, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China [5]Univ Hong Kong, Dept Ophthalmol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China [6]Univ Hong Kong, State Key Lab Brain & Cognit Sci, Pokfulam, Hong Kong, Peoples R China [7]Jinan Univ, GMH Inst Cent Nervous Syst Regenerat, Guangzhou, Guangdong, Peoples R China [8]Univ Hong Kong, Fac Med, Res Ctr Heart Brain Hormone & Hlth Aging, Pokfulam, Hong Kong, Peoples R China
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关键词: nerve regeneration traditional Chinese medicine Lycium barbarum polysaccharides Lycium barbarum (wolfberry) retinal disease neurogenesis adult neural regeneration

摘要:
Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.

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出版当年[2014]版:
大类 | 4 区 医学
小类 | 4 区 细胞生物学 4 区 神经科学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
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出版当年[2013]版:
Q4 CELL BIOLOGY Q4 NEUROSCIENCES
最新[2023]版:
Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China [2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China [2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China [4]Univ Hong Kong, Dept Anat, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China [5]Univ Hong Kong, Dept Ophthalmol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China [6]Univ Hong Kong, State Key Lab Brain & Cognit Sci, Pokfulam, Hong Kong, Peoples R China [7]Jinan Univ, GMH Inst Cent Nervous Syst Regenerat, Guangzhou, Guangdong, Peoples R China [8]Univ Hong Kong, Fac Med, Res Ctr Heart Brain Hormone & Hlth Aging, Pokfulam, Hong Kong, Peoples R China
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