机构：[1]TongRen Hospital, School of Medicine, Shanghai Jiao Tong University,[2]Shanghai Institute of Materia Medica, Chinese Academy of Sciences,[3]Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University,[4]Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China
The structural features of bone engineering scaffolds are expected to exhibit osteoinductive behavior and promote cell adhesion, proliferation, and differentiation. In the present study, we employed synthesized ordered mesoporous calcium-magnesium silicate (om-CMS) and polybutylene succinate (PBSu) to develop a novel scaffold with potential applications in osseous tissue engineering. The characteristics, in vitro bioactivity of om-CMS/PBSu scaffold, as well as the cellular responses of MC3T3-E1 cells to the composite were investigated. Our results showed that the om-CMS/PBSu scaffold possesses a large surface area and highly ordered channel pores, resulting in improved degradation and biocompatibility compared to the PBSu scaffold. Moreover, the om-CMS/PBSu scaffold exhibited significantly higher bioactivity and induced apatite formation on its surface after immersion in the simulated body fluid. In addition, the om-CMS/PBSu scaffold provided a high surface area for cell attachment and released Ca, Mg, and Si ions to stimulate osteoblast proliferation. The unique surface characteristics and higher biological efficacy of the om-CMS/PBSu scaffold suggest that it has great potential for being developed into a system that can be employed in osseous tissue engineering.
基金：
National Nature Science Foundation of China
(grant number: 81201177 and 81571796), Youth Innovation
Promotion Association, CAS, and the SA-SIBS Scholarship
Program.
第一作者机构：[1]TongRen Hospital, School of Medicine, Shanghai Jiao Tong University,[2]Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
共同第一作者：
通讯作者：
通讯机构：[1]TongRen Hospital, School of Medicine, Shanghai Jiao Tong University,[4]Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China[*1]Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, 1111 Xianxia Road, Shanghai 200336, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhang Xinxin,Zhang Chi,Xu Wei,et al.Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering[J].INTERNATIONAL JOURNAL OF NANOMEDICINE.2015,10:6699-6708.doi:10.2147/IJN.S92598.
APA：
Zhang, Xinxin,Zhang, Chi,Xu, Wei,Zhong, Biao,Lin, Feng...&Zhang, Yang.(2015).Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,
MLA：
Zhang, Xinxin,et al."Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering".INTERNATIONAL JOURNAL OF NANOMEDICINE 10.(2015):6699-6708
