Objective: To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI). Method: Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3. Results: Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively). Conclusion: Exogenous CP was helpful to reduce myocardial injury after PCI.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100143]; Beijing Municipal Education CommissionBeijing Municipal Commission of Education [KZ201110025031]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z0005190042811]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [Z121107002512053]
第一作者机构:[1]Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing 100029, Peoples R China[2]Capital Med Univ, Dept Cardiol, Beijing Tongren Hosp, Beijing 100029, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing 100029, Peoples R China[*1]Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, 12th Ward, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714):
Deng Ke-Wu,Shi Xu-Bo,Zhao Ying-Xin,et al.The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention[J].ANGIOLOGY.2015,66(2):163-168.doi:10.1177/0003319713515996.
APA:
Deng Ke-Wu,Shi Xu-Bo,Zhao Ying-Xin,Yang Shi-Wei,Zhou Yu-Jie...&Ma Chang-Sheng.(2015).The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention.ANGIOLOGY,66,(2)
MLA:
Deng Ke-Wu,et al."The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention".ANGIOLOGY 66..2(2015):163-168