Predictive models for adverse clinical outcomes in Chinese patients with atrial fibrillation undergoing percutaneous coronary intervention with stenting
机构:[a]Department of Cardiology, Division of Cardiology and Cardiovascular Surgery, 6th Medical Center of PLA General Hospital, Beijing, China[b]Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China[c]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院[d]Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室心血管中心首都医科大学附属北京同仁医院首都医科大学附属同仁医院[e]Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
Objective This study aimed to evaluate predictors for adverse cardiovascular outcomes in patients with atrial fibrillation (AF) undergoing coronary stenting. Methods We retrospectively recruited consecutive patients with previously documented non-valvular AF who underwent coronary stenting between January 2010 and June 2015 in 12 hospitals of Beijing, China. Major adverse cardiac/cerebrovascular events (MACCE) were a composite of all-cause death, non-fatal myocardial infarction, repeat revascularization, and ischaemic stroke/systemic thromboembolism (IS/STE). Major bleeding referred to grade 2 or higher of Bleeding Academic Research Consortium criteria. Results A total of 2394 patients (men: 72.3% vs. women: 27.7%, median age: 67 years) were included. The CHA(2)DS(2)-VASc and HAS-BLED were 3.6 +/- 1.6 and 1.9 +/- 0.7, respectively. The median follow-up duration was 36.2 months. There were 230 (9.6%) deaths, 96 (4.0%) IS/STE, 426 (17.8%) MACCE, and 72 (3.0%) major bleeding. Multivariate Cox regression yielded predictive models for (1) all-cause death: diabetes, prior myocardial infarction, chronic kidney disease (CKD), ST-segment elevation myocardial infarction (STEMI) at presentation, heart failure, no use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and statins; (2) IS/STE: advanced age, prior history of ischaemic stroke and intracranial haemorrhage; (3) MACCE: prior history of myocardial infarction and ischaemic stroke, CKD, STEMI, heart failure, and no statin use; (4) major bleeding: prior major bleeding, prior myocardial infarction, CKD and use of oral anticoagulants. Conclusion Chinese patients with AF and coronary stenting had high mortality and incidence of MACCE. We compiled separate predictive models for all-cause death, IS/STE, MACCE, and major bleeding.
基金:
This work was supported by Chinese PLA General Hospital
under Grant number: 2019MBD-057 and Beijing Municipal
Science and Technology Commission under Grant number:
Z151100004015205.
第一作者机构:[a]Department of Cardiology, Division of Cardiology and Cardiovascular Surgery, 6th Medical Center of PLA General Hospital, Beijing, China
共同第一作者:
通讯作者:
通讯机构:[a]Department of Cardiology, Division of Cardiology and Cardiovascular Surgery, 6th Medical Center of PLA General Hospital, Beijing, China[*1]Department of Cardiology, Division of Cardiology and Cardiovascular Surgery, Sixth Medical Center of PLA General Hospital, No. 6 Fucheng Road, Haidian District, Beijing, China.
推荐引用方式(GB/T 7714):
Jian-Yong Zheng,Yi Cao,Dong-Tao Li,et al.Predictive models for adverse clinical outcomes in Chinese patients with atrial fibrillation undergoing percutaneous coronary intervention with stenting[J].ACTA CARDIOLOGICA.2022,77(4):360-365.doi:10.1080/00015385.2021.1950367.
APA:
Jian-Yong Zheng,Yi Cao,Dong-Tao Li,Yi-Gang Qiu,Li Zhao...&Yu Chen.(2022).Predictive models for adverse clinical outcomes in Chinese patients with atrial fibrillation undergoing percutaneous coronary intervention with stenting.ACTA CARDIOLOGICA,77,(4)
MLA:
Jian-Yong Zheng,et al."Predictive models for adverse clinical outcomes in Chinese patients with atrial fibrillation undergoing percutaneous coronary intervention with stenting".ACTA CARDIOLOGICA 77..4(2022):360-365