机构：[1]Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China[2]Department of Immunology of Shanghai Medical School and Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China[3]Department of Digestive Diseases, Yangpu Hospital, Tongji University School of Medicine, 450 Tengyue Road, Shanghai 200090, China[4]Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China[5]Department of Clinical Laboratory, Shanghai Tongren Hospital, 786 Yuyuan Road, Shanghai 200050, China[6]Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai 200438, China[7]Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lake Shore Drive, Chicago, IL 60611, USA[8]Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E. Superior, Chicago, IL 60611, USA
Increasing studies suggest that microRNAs, a new group of small non-coding molecules, regulate the expression of their target genes and play some roles in cancers. Thus, it is hypothesized that the genetic variants of microRNAs could contribute to the susceptibility to cancers. In this study, the association between rs67106263 in microRNA-3144 and the risk of hepatocellular carcinoma (HCC) was explored in a large-scaled case-control population based on MassARRAY technology. It was discovered that compared with the carriers of wide-type GG genotype and heterozygote GA genotype of microRNA-3144, the significantly increased risk of HCC was observed in the subjects with the homozygote variant AA (adjusted odds ratio = 1.285, 95 % confidence interval = 1.004-1.643, P = 0.046). Additionally, the variant was also associated with the expression of alpha fetoprotein (AFP), which is the diagnostic marker for HCC. Our findings suggest for the first time that rs67106263 may play some roles in the risk of HCC, expecting future molecular researches to elucidate the possible mechanisms behind these results.
基金：
Ministry of Science and Technology of China (No. 2013CB945401)
and Shanghai Municipal Commission of Health and Family Planning
(No. 20134132)
第一作者机构：[1]Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China[2]Department of Immunology of Shanghai Medical School and Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
推荐引用方式(GB/T 7714)：
Zhang Jun,Wang Rui,Cai Min,et al.Association of microRNA-3144 variant with the susceptibility to hepatocellular carcinoma[J].GENES & GENOMICS.2014,36(6):771-776.doi:10.1007/s13258-014-0211-z.
APA：
Zhang, Jun,Wang, Rui,Cai, Min,Yu, Shunji,Ma, Yanyun...&Liu, Jie.(2014).Association of microRNA-3144 variant with the susceptibility to hepatocellular carcinoma.GENES & GENOMICS,36,(6)
MLA：
Zhang, Jun,et al."Association of microRNA-3144 variant with the susceptibility to hepatocellular carcinoma".GENES & GENOMICS 36..6(2014):771-776
