To evaluate the short-term prognosis of pediatric hepatoblastoma (HB) in relation to excision repair cross-complementation gene 1 (ERCC1)C118T single nucleotide polymorphism (SNP) and VEGF expression. ERCC1 C118T SNP and VEGF expression were detected and investigated in 31 children with HB undergoing platinum-based chemotherapy, to analyze their relationship with short-term pediatric HB prognosis. CC (38.7%; 12/31), CT (35.5%; 11/31), and TT (25.8%; 8/31) ERCC1 C118T mutation types were identified. The Kaplan-Meier survival curve analysis showed that the CC group had a better short-term prognosis than the CT + TT group (p = 0.010). VEGF was overexpressed in 14 cases (45.2%) and underexpressed in 17 cases (54.8%). The Kaplan-Meier survival curve analysis showed that the high VEGF expression group showed poorer short-term prognosis than the lower VEGF expression group (p = 0.004). In this study, ERCC1 C118T SNP in children with HB was mainly found to be mutant type CT + TT. Compared to wild type CC, children with the mutant type CT + TT exhibited better treatment efficacy and remission with platinum-based chemotherapy as well as better survival rates. Moreover, the short-term prognosis of children with low VEGF expression was better than in those with high expression.
基金：
Beijing Yizhuang Economic
and Technological Development Zone Leading Talent
Program [(2017)-8].
第一作者机构：[1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*1]Department of Pediatrics Beijing Tongren Hospital, Capital Medical University No. 1 Dongjiaominxiang Dongcheng District Beijing 100176, China
推荐引用方式(GB/T 7714)：
Wen Yuan,Zhang Weiling,Zhang Yi,et al.SHORT-TERM PROGNOSIS OF CHILDHOOD HEPATOBLASTOMA IN RELATION TO ERCCI C118T SINGLE NUCLEOTIDE POLYMORPHISM AND VEGF EXPRESSION[J].POLISH JOURNAL OF PATHOLOGY.2019,70(4):304-310.doi:10.5114/PJP.2019.93134.
APA：
Wen, Yuan,Zhang, Weiling,Zhang, Yi,Hu, Huimin,Li, Jing&Huang, Dongsheng.(2019).SHORT-TERM PROGNOSIS OF CHILDHOOD HEPATOBLASTOMA IN RELATION TO ERCCI C118T SINGLE NUCLEOTIDE POLYMORPHISM AND VEGF EXPRESSION.POLISH JOURNAL OF PATHOLOGY,70,(4)
MLA：
Wen, Yuan,et al."SHORT-TERM PROGNOSIS OF CHILDHOOD HEPATOBLASTOMA IN RELATION TO ERCCI C118T SINGLE NUCLEOTIDE POLYMORPHISM AND VEGF EXPRESSION".POLISH JOURNAL OF PATHOLOGY 70..4(2019):304-310
