Purpose: Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRs) have been shown to be associated with susceptibility to several types of human cancer. However, the association of miR-933 rs79402775 with gastric cancer (GC) has not been explored. Methods: The association between rs79402775 in miR933 and the risk of GC was explored in Chinese population based on MassARRAY technology. A total 374 GC patients and 999 cancer-free controls were enrolled in this study. Results: Compared with the wild-type GG, GA genotype was associated with a significantly decreased risk of GC (OR=0.542, 95% CI= 0.299-0.983, p= 0.044) in female subjects. Moreover, the variant was also associated with the expression of alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA). Conclusions: miR-933(rs79402775) may contribute to decreased susceptibility to GC and this SNP could be developed as a biomarker for GC prognosis.
基金：
Health and Family Planning Commission of Shanghai Municipality [20134132]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2013CB945401, 2012CB910104]
第一作者机构：[1]Fudan Univ, Huashan Hosp, Dept Digest Dis, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Fudan Univ, Huashan Hosp, Dept Digest Dis, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China[*1]Department of Digestive Diseases, Huashan Hospital, Fudan University 12 Middle Wulumuqi Rd., Shanghai 200040 China
推荐引用方式(GB/T 7714)：
Zhang Yitong,Ma Yanyun,Xu Weihong,et al.Association of microRNA-933 variant with the susceptibility to gastric cancer[J].JOURNAL OF BUON.2017,22(2):390-395.
APA：
Zhang, Yitong,Ma, Yanyun,Xu, Weihong,Li, Wenshuai,Min, Pei...&Zhang, Jun.(2017).Association of microRNA-933 variant with the susceptibility to gastric cancer.JOURNAL OF BUON,22,(2)
MLA：
Zhang, Yitong,et al."Association of microRNA-933 variant with the susceptibility to gastric cancer".JOURNAL OF BUON 22..2(2017):390-395
