机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, No. 1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, China.研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]School of Life Sciences, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China.[3]Henan Academy of Innovations in Medical Science, No. 2 Biotechnology Street, Hangkonggang District, Zhengzhou 450000, China.
Normal tension glaucoma (NTG) is becoming a more and more serious problem, especially in Asia. But the pathological mechanisms are still not illustrated clearly. We carried out this research to uncover the gene polymorphisms with NTG.We searched in Web of Science, Embase, Pubmed and Cochrane databases for qualified case-control studies investigating the association between single nucleotide polymorphisms (SNPs) and NTG risk. Odds ratios (ORs) and 95% confidence intervals (CIs) for each SNP were estimated by fixed- or random-effect models. Sensitivity analysis was also performed to strengthen the reliability of the results.Fifty-six studies involving 33 candidate SNPs in 14 genetic loci were verified to be eligible for our meta-analysis. Significant associations were found between 16 SNPs (rs166850 of OPA1; rs10451941 of OPA1; rs735860 of ELOVL5; rs678350 of HK2; c.603T>A/Met98Lys of OPTN; c.412G>A/Thr34Thr of OPTN; rs10759930 of TLR4; rs1927914 of TLR4; rs1927911 of TLR4; c.*70C>G of EDNRA; rs1042522/-Arg72Pro of P53; rs10483727 of SIX1-SIX6; rs33912345 of SIX1-SIX6; rs2033008 of NCK2; rs3213787 of SRBD1 and c.231G>A of EDNRA) with increased or decreased risk of NTG.In this study, we confirmed 16 genetic polymorphisms in 10 genes (OPA1, ELOVL5, HK2, OPTN, TLR4, EDNRA, P53, NCK2, SRBD1 and SIX1-SIX6) were associated with NTG.
基金：
The study is supported by National Natural Science Foundation of China (GZR-2012–009);
Beijing Traditional Chinese Medicine Technology Development, Fund Project (JJ2018-50).
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, No. 1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, China.
通讯作者：
通讯机构：[2]School of Life Sciences, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China.[3]Henan Academy of Innovations in Medical Science, No. 2 Biotechnology Street, Hangkonggang District, Zhengzhou 450000, China.
推荐引用方式(GB/T 7714)：
Pan Lijie,Wu Jian,Wang Ningli.Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis[J].GENES.2024,15(4):doi:10.3390/genes15040491.
APA：
Pan Lijie,Wu Jian&Wang Ningli.(2024).Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis.GENES,15,(4)
MLA：
Pan Lijie,et al."Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis".GENES 15..4(2024)
