Objective: The purpose of this study was to investigate the association between IL-1A (-889C/T, rs1800587) polymorphism and susceptibility of chronic periodontitis. Methods: A systematic literature search was carried out in the databases updated on July 1, 2019, including PubMed, Embase, Cochrane Library and Web of Science. Through STATA 14.0 software, the association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis was calculated by pooled odds rations (ORs) and 95% confidence intervals (CIs). Harbord test was used for the publication bias. Results: The results of overall meta-analysis revealed that IL-lA (-889C/T) polymorphism was associated with the susceptibility of chronic periodontitis among all the genetic models, including allele contrast [T vs. C, OR (95% CI): 1.297 (1.038-1.622), P = 0.022], dominant model [Tr + CT vs. CC, OR (95% CI): 1.337 (1.015-1.761), P = 0.039], recessive model [TT vs. CC + CT, OR (95% CI): 1.453 (1.138-1.856), P = 0.003], and codominant model [FT vs. CC, OR (95% CI): 1.555 (1.187-2.038), P = 0.001; CT vs. CC, OR (95% CI): 2.559 (1.245-5.260), P = 0.011]. The results of subgroup analyses indicated that IL-1A (-889C/T) polymorphism was closely related to the susceptibility of chronic periodontitis in African population [T vs. C, OR (95% CI): 1.277 (1.039-1.571), P = 0.020; TT + CT vs. CC, OR (95% CI): 1.357 (1.061-1.735), P = 0.015; TT vs. CC, OR (95% CI): 1.599 (1.115-2.292), P = 0.011], in European population [TT vs. CC + CT, OR (95% CI): 1.645 (1.112-2.435), P = 0.013; TT vs. CC, OR (95% CI): 1.639 (1.044-2.574), P = 0.032] and in American population [CT vs. CC, OR (95% CI): 6.404 (3.000-13.669), P < 0.001]. Conclusions: IL-1A (-889C/T) polymorphism is associated with the susceptibility of chronic periodontitis in African, European and American populations according to the currently available evidence.
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Stomatol, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[2]Capital Med Univ, Beijing Stomatol Hosp, Dept Oral & Maxillofacial Surg, 4 Tiantan Xili, Beijing 100050, Peoples R China[*1]Department of Oral and Maxillofacial Surgery, Beijing Stomatology Hospital Affiliated to Capital Medical University, No. 4 Tiantan Xili, Dongcheng District, Beijing 100050, PR China
推荐引用方式(GB/T 7714)：
Feng Xiaodong,Liu Jingming.Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis[J].GENE.2020,729:doi:10.1016/j.gene.2019.144227.
APA：
Feng, Xiaodong&Liu, Jingming.(2020).Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis.GENE,729,
MLA：
Feng, Xiaodong,et al."Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis".GENE 729.(2020)
