Histone deacetylases (HDACs) are important in chromatin remodeling and epigenetic regulation of gene expression. Histone deacetylase inhibitors (HDACi) have highly effective anti-metastatic and anti-angiogenic activity in various types of cancer, while the molecular mechanisms involved in this process are not fully understood. In the present study, trichostatin A (TSA), a HDACi, was found to suppress MCF-7 breast carcinoma cell invasion and upregulate TET1 expression in a dose-dependent manner. TET1, a dioxygenase involved in cytosine demethylation, is downregulated during breast cancer progression. TET1 knockdown in MCF-7 cells facilitates cell invasion, inhibits the expression of tissue inhibitors of metalloproteinase 2/3 (TIMP2/3) and promotes matrix metalloproteinases (MMP) 2/9 transcriptional activity. Importantly, TET1 depletion impaired the inhibitory effect of TSA on breast cancer cell invasion. Together, these results illustrated a mechanism by which TET1 partially mediates HDACi elicited suppression of breast cancer invasion.
第一作者机构：[1]Cent Hosp Jingzhou, Dept Orthoped, Jinzhou 434100, Hubei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[8]Shanghai Tongren Hosp Changning, Dept Surg, Shanghai 200050, Peoples R China[*1]Department of Surgery, Shanghai Tongren Hospital of Changning, 768 Yuyuan Road, Shanghai 200050, P.R. China
推荐引用方式(GB/T 7714)：
Lu Hou-Gen,Zhan Wang,Yan Lin,et al.TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion[J].MOLECULAR MEDICINE REPORTS.2014,10(5):2595-2600.doi:10.3892/mmr.2014.2517.
APA：
Lu, Hou-Gen,Zhan, Wang,Yan, Lin,Qin, Rui-Ying,Yan, Yi-Peng...&Chen, Guo-Qing.(2014).TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion.MOLECULAR MEDICINE REPORTS,10,(5)
MLA：
Lu, Hou-Gen,et al."TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion".MOLECULAR MEDICINE REPORTS 10..5(2014):2595-2600
