机构：[1]Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院[2]Department of Respiratory Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院[3]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Objective To assess the macular retina and choroidal thickness change in patients with obstructive sleep apnea-hypopnea syndrome (OSAS) with no significant symptoms and pathological changes in the fundus using spectral domain-optical coherence tomography. Methods This prospective, observational case-control study consisted of 53 eyes of 53 patients with OSAS and 12 eyes of 12 age-matched controls. Macular and choroidal thicknesses were measured by optical coherence tomography. Results The foveal and nasal macular thicknesses were significantly different between four groups (P = 0.001, P = 0.016). The foveal thickness of the control group was significantly thinner than that of the severe group (P = 0.000). The nasal macular thickness of the control group was significantly thinner than that of the severe group (P = 0.008). A significant correlation was found between oxygen desaturation index (ODI) and macular center thickness (r = 0.357, R 2 = 0.127, P = 0.004), with an ODI coefficient of 0.457 (P = 0.004). Similarly, a significant correlation was found between ODI and nasal macular thickness (r = 0.265, R 2 = 0.070, P = 0.033), with an ODI coefficient of 0.233 (P = 0.033). The subfoveal choroidal thickness was significantly different among the groups (F = 3.657, P = 0.017). The subfoveal choroidal thickness of the severe group was significantly thinner than that of the control group, mild group, and moderate group (P = 0.023, 0.006, and 0.036, respectively). The choroidal thickness 1mm nasal to the fovea was significantly different between the groups after correcting for age and diopter (F = 3.411, P = 0.023). The choroidal thickness 1mm nasal to the fovea was significantly thinner in the severe group compared with the control group and mild group (P = 0.013 and 0.010, respectively). Choroidal thickness was significantly correlated with diopter (r = 0.520, R 2 = 0.270, P < 0.001), with a coefficient of 0.327 (P < 0.001), and with ODI (r = 0.520, R 2 = 0.165, P = 0.001), with a coefficient of = 0.370 (P = 0.001). Conclusions OSAS patients showed decreased foveal and nasal macular thickness, similar to the subfoveal and nasal choroidal thickness. These findings suggest that, because of intermittent hypoxia, OSAS might change the retinal and choroidal blood supply. Eye (2014) 28, 415-421; doi: 10.1038/eye.2013.307; published online 10 January 2014
第一作者机构：[1]Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[3]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Nei Street, Dongcheng district, Beijing 10005, China
推荐引用方式(GB/T 7714)：
Xin C.,Wang J.,Zhang W.,et al.Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)[J].EYE.2014,28(4):415-421.doi:10.1038/eye.2013.307.
APA：
Xin, C.,Wang, J.,Zhang, W.,Wang, L.&Peng, X..(2014).Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS).EYE,28,(4)
MLA：
Xin, C.,et al."Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)".EYE 28..4(2014):415-421
