Quantitative evaluation of retinal microvascular circulation in patients with obstructive sleep apnea-hypopnea using optical coherence tomography angiography.
机构：[1]Department of Ophthalmology & Clinical Centre of Optometry, Peking University People’s Hospital, Beijing, China[2]Eye Diseases and Optometry Institute, Beijing, China[3]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China[4]College of Optometry, Peking University Health Science Center, Beijing, China[5]Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing 100044, China
To compare capillaries perfusion in macular areas at different layers and peripapillary region in radial peripapillary capillaries (RPC) between healthy subjects and subjects with obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA).Totally 16 eyes with mild-to-moderate OSA, 14 eyes with severe OSA and 22 control eyes were enrolled in this study. Every subject filled out the Berlin questionnaire and received a comprehensive ocular and physical examination. The clinical characteristics were collected, OCT and OCTA scans using OCTA RT XR Avanti (AngioVue software, Optovue Inc., Fremont, CA, USA) were performed and analyzed.Compared to the control group, the severe group had significantly higher VD in parafovea and perifoveal regions (p = 0.031; p = 0.029) at the level of deep capillary plexus (DCP), whereas the mild-to-moderate group had a significantly lower VD in the peripapillary region on RPC network in disc areas (p = 0.013).Blood flow changes in macular areas might first appear at the DCP layer in OSA patients. Reduced VD in the peripapillary region at the RPC layer might be associated with OSA and cause subsequent RNFL changes.
基金：
National Natural
Science Foundation of China (Grant No. 81970815).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区眼科学
最新[2023]版：
大类|4 区医学
小类|4 区眼科学
第一作者：
第一作者机构：[1]Department of Ophthalmology & Clinical Centre of Optometry, Peking University People’s Hospital, Beijing, China[2]Eye Diseases and Optometry Institute, Beijing, China[3]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China[4]College of Optometry, Peking University Health Science Center, Beijing, China
通讯作者：
通讯机构：[1]Department of Ophthalmology & Clinical Centre of Optometry, Peking University People’s Hospital, Beijing, China[2]Eye Diseases and Optometry Institute, Beijing, China[3]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China[4]College of Optometry, Peking University Health Science Center, Beijing, China
推荐引用方式(GB/T 7714)：
Yi Cai,Guo-Sheng Sun,Long Zhao,et al.Quantitative evaluation of retinal microvascular circulation in patients with obstructive sleep apnea-hypopnea using optical coherence tomography angiography.[J].International ophthalmology.2020,40(12):3309-3321.doi:10.1007/s10792-020-01518-x.
APA：
Yi Cai,Guo-Sheng Sun,Long Zhao,Fang Han,Ming-Wei Zhao&Xuan Shi.(2020).Quantitative evaluation of retinal microvascular circulation in patients with obstructive sleep apnea-hypopnea using optical coherence tomography angiography..International ophthalmology,40,(12)
MLA：
Yi Cai,et al."Quantitative evaluation of retinal microvascular circulation in patients with obstructive sleep apnea-hypopnea using optical coherence tomography angiography.".International ophthalmology 40..12(2020):3309-3321
