机构：[1]Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, Ghent B-9000, Belgium.[2]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, PR China.首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科[3]Key Laboratory of Otolaryngology, Head and Neck Surgery (Ministry of Education of China), Beijing Institute of Otorhinolaryngology, Beijing 100005, PR China.首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[4]Department of Mathematical Modelling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.[5]Karolinska Institutet, Division of ENT Diseases, CLINTEC, Stockholm, Sweden
Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylation analysis. Results showed that SEB stimulation altered the methylation pattern of gene regions when compared with non stimulated tissue. Data enrichment analysis highlighted two genes: the IKBKB and STAT-5B, both playing a crucial role in T- cell maturation/activation and immune response.
基金：
This work was supported by the grant to Dr. Claudina A. Pérez-Novo from the
Flemish Research Board (FWO Postdoctoral mandate, Nr.FWO08-PDO-117), a
grant to Prof. Claus Bachert from the Flemish Scientific Research Board
(FWO Nr. A12/5-HB-KH3 and G.0436.04). Simon Denil is supported by IWT
doctoral research grant SB101371
第一作者机构：[1]Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, Ghent B-9000, Belgium.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Perez-Novo Claudina A.,Zhang Yuan,Denil Simon,et al.Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study[J].ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY.2013,9:doi:10.1186/1710-1492-9-48.
APA：
Perez-Novo, Claudina A.,Zhang, Yuan,Denil, Simon,Trooskens, Geert,De Meyer, Tim...&Bachert, Claus.(2013).Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study.ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY,9,
MLA：
Perez-Novo, Claudina A.,et al."Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study".ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY 9.(2013)
