机构：[1]Tongren Eye Center, Beijing Key Laboratory of Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China[3]Department of Ophthalmology, Zaozhuang Municipal Hospital, Shandong Province, China[4]Division of Glaucoma, Anyang Eye Hospital, Henan Province, China[5]Queensland Eye Institute and University of Queensland, Queensland, Australia[6]Division of Glaucoma, Handan Eye Hospital, Hebei Province, China[7]Division of Glaucoma, Fushun Eye Hospital, Liaoning Province, China
Purpose To evaluate the association between early and late postoperative intraocular pressure (IOP) and determine if early postoperative IOP can predict the surgical outcome. Methods A total of 165 consecutive patients with primary angle-closure glaucoma (PACG) undergoing primary mitomycin-C-augmented trabeculectomy underwent a comprehensive eye examination before surgery and were followed-up on days 1, 7, 14, and 30, and months 3, 6, 12, and 18. IOPs on days 1, 7, 14, and 30 were stratified into groups A (<10mmHg), B (>= 10 and <15mmHg), C (>= 15 and <20mmHg), and D (>= 20mmHg). Differences between groups were analyzed using analysis of variance (ANOVA) and Fisher's exact test. Multivariable regression was used to exam the predictive ability of early IOP for final outcome. Results The mean age was 62.5 +/- 7.9 years and 41.21% (n = 68) were males. Stratified by IOP on days 1, 7, 14, and 30, respectively, mean IOPs at month 18 were different among groups A, B, C, and D (ANOVA, P = 0.047, P = 0.033, P = 0.008, and P<0.001, respectively). Once the IOPs were settled with interventions on day 7 a higher IOP level was associated with decreasing success rate under different outcome definitions, final IOP <15mmHg (Fisher's exact P = 0.001) and <20mmHg (P = 0.039) without medication. Multiple regression showed early IOP predicted final IOP independently from baseline variables. A cutoff value of 13.5 mm Hg on day 7 achieved an accuracy of 80.0 and 57.1% in predicting IOP <15 mm Hg without medication and failure after surgery, respectively. Conclusions The IOP at 18 months following primary antifibrotic-augmented trabeculectomy in PACG patients is associated with and predicted by the postoperative IOPs at 1 month. Control of early IOP to 13.5 or less may provide better outcomes. Eye (2013) 27, 403-409; doi:10.1038/eye.2012.291; published online 11 January 2013
基金：
Ministry of Science and Technology of the PRC [2007BAI18B08]
第一作者机构：[1]Tongren Eye Center, Beijing Key Laboratory of Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China[2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
通讯作者：
通讯机构：[1]Tongren Eye Center, Beijing Key Laboratory of Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China[2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China[*1]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 4/F, 147K, Argyle Street, Kowloon, Hong Kong, China.
推荐引用方式(GB/T 7714)：
SS Rong,MY Feng,N Wang,et al.Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma[J].EYE.2013,27(3):403-409.doi:10.1038/eye.2012.291.
APA：
SS Rong,MY Feng,N Wang,H Meng,R Thomas...&YB Liang.(2013).Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma.EYE,27,(3)
MLA：
SS Rong,et al."Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma".EYE 27..3(2013):403-409
