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Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells

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收录情况： ◇ SCIE

作者：
Feng, Guofang[1] * ; Wang, Xiaoqing[2] ; You, Changxuan[3] ; Cheng, Xiaohua[4] ; Han, Zeli[1] ; Zong, Liang[1] ; Zhou, Chengyong[1] ; Zhang, Meikui[5] ;
机构： [1]Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Beijing 100048, Peoples R China [2]Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Pharmacol, Beijing 100048, Peoples R China [3]Southern Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou 510515, Guangdong, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Otolaryngol, Beijing 100005, Peoples R China [5]Chinese Peoples Liberat Army Gen Hosp, Tel Consultat Med Ctr, Beijing 100853, Peoples R China
出处：
DOI： 10.1016/j.carbpol.2012.10.024
ISSN：

关键词： Artemisia capillaris Polysaccharide Apoptosis Nasopharyngeal carcinoma

摘要：
One water-soluble polysaccharide fraction (WACP) was purified from the Artemisia capillaris by DEAE-cellulose anion-exchange and Sephacryl S-400 gel-permeation chromatography. Based on gas chromatography (GC) analysis, WACP was an arabinogalactan (AG), consisting of arabinose and galactose in the ratio of 4:2. Its molecular weight was about 5.8 x 10(4) Da. The present study demonstrated the anticancer potential of WACP on human nasopharyngeal carcinoma CNE-2 cells and elucidated its possible mechanisms. MIT and flow cytometric analysis identified that WACP had a potent anti-proliferation activity on CNE-2 cells by inducing apoptosis, which was parallel with the morphological changes of CNE-2 cells under inverted microscope. In addition, WACP triggered the apoptosis via the mitochondrial apoptotic pathway, which included the loss of mitochondrial membrane potential, release of cytochrome c and activation of caspase-3/9. Taken together, these results suggest that WACP has anticancer potential in the treatment of human nasopharyngeal carcinoma. (C) 2012 Elsevier Ltd. All rights reserved.

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外文
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中科院(CAS)分区：
出版当年[2012]版：
大类 | 3 区 化学
小类 | 1 区 应用化学 2 区 高分子科学 3 区 有机化学
最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
JCR分区：
出版当年[2011]版：
Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE Q1 CHEMISTRY, ORGANIC
最新[2023]版：
Q1 POLYMER SCIENCE Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者机构： [1]Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Beijing 100048, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Feng Guofang,Wang Xiaoqing,You Changxuan,et al.Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells[J].CARBOHYDRATE POLYMERS.2013,92(2):1040-1045.doi:10.1016/j.carbpol.2012.10.024.
APA：
Feng, Guofang,Wang, Xiaoqing,You, Changxuan,Cheng, Xiaohua,Han, Zeli...&Zhang, Meikui.(2013).Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells.CARBOHYDRATE POLYMERS,92,(2)
MLA：
Feng, Guofang,et al."Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells".CARBOHYDRATE POLYMERS 92..2(2013):1040-1045

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