Serum antibodies to 25 myelin oligodendrocyte glycoprotein epitopes in multiple sclerosis and neuromyelitis optica: clinical value for diagnosis and disease activity
Background Whether antibody to myelin oligodendrocyte glycoprotein (MOO) can be a diagnostic marker for multiple sclerosis (MS) is still controversial. Recent studies suggested that serum specific anti-MOG epitope antibody might be an MS specific marker. However, these studies did not include neuromyelitis optica (NMO) which might be proven to also have anti-MOO antibody. Hence, the present study was undertaken to investigate the clinical value of serum antibodies to 25 MOG epitopes in conventional MS (CMS) and NMO. Methods Serum anti-MOO epitope IgG was detected in 61 CMS patients, 54 NMO patients, and 77 healthy controls, using enzyme-linked immunosorbent assay (ELISA). Results Anti-MOG(27-38) IgG levels in both CMS and NMO patients were significantly higher than that in healthy controls (optical density (OD): 0.64+/-0.38, 0.48+/-0.23 vs. 0.19+/-0.09; P=0.000). CMS and NMO patients in relapse stage had significantly higher anti-MOG(27-38) IgG level than patients in remission stage (OD: 0.55+/-0.14 vs. 0.24+/-0.09, P=0.027). Conclusion Although serum anti-MOO epitope IgG could not differentiate MS from NMO, it may be a useful marker for monitoring disease activity. Chin Med J 2012;125(18):3207-3210
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7093128]; Peking Union Medical College Hospital [2009115]
第一作者机构：[1]Peking Union Med Coll Hosp, Dept Neurol, Beijing 100730, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Yan,Zhang Yao,Liu Cai-yan,et al.Serum antibodies to 25 myelin oligodendrocyte glycoprotein epitopes in multiple sclerosis and neuromyelitis optica: clinical value for diagnosis and disease activity[J].CHINESE MEDICAL JOURNAL.2012,125(18):3207-3210.doi:10.3760/cma.j.issn.0366-6999.2012.18.002.
APA：
Xu Yan,Zhang Yao,Liu Cai-yan,Peng Bin,Wang Jian-ming...&Cui Li-ying.(2012).Serum antibodies to 25 myelin oligodendrocyte glycoprotein epitopes in multiple sclerosis and neuromyelitis optica: clinical value for diagnosis and disease activity.CHINESE MEDICAL JOURNAL,125,(18)
MLA：
Xu Yan,et al."Serum antibodies to 25 myelin oligodendrocyte glycoprotein epitopes in multiple sclerosis and neuromyelitis optica: clinical value for diagnosis and disease activity".CHINESE MEDICAL JOURNAL 125..18(2012):3207-3210
