Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells
Trichostatin A (TSA) is classical Histone deacetylase inhibitors (HDACIs) II which is used in treatment of advanced cutaneous T-cells lymphoma. Our works focused on the roles of TSA on immuno-modulatory. We found that the TSA could induce resting Teff cells into apoptotic cell death and inhibit Teff cells proliferation in a dose-dependent manner. We also observed down-regulation effects of various costimulatory/adhesion molecules on Teff cells and up-regulation of Foxp3 expression on CD4+ CD25+ T cells. Treatment with TSA could improve mice corneal allograft survival by promoting the proportions and allosuppressive function of CD4+ CD25+ regulatory T cells. Our findings suggest that the use of TSA allows the beneficial pharmacological effect on CD4+ CD25 - T activation in vitro and enhancement of Foxp3+ Treg cells in vivo. (C) 2012 Elsevier Inc. All rights reserved.
基金：
Scientific Research Key Program of Beijing Municipal Commission of Education Grant [KZ200910025009]; Beijing Health Systems High-level Health and Technical Talent Training Plan [2009-2-05]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30801264]; Nova Program [2007B050]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalm & Visual Sci Key Lab, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalm & Visual Sci Key Lab, Beijing 100730, Peoples R China[*1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalm & Visual Sci Key Lab, 1 DongjiaoMinxiang, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Guo Xuming,Jie Ying,Ren Dong,et al.Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells[J].CELLULAR IMMUNOLOGY.2012,277(1-2):8-13.doi:10.1016/j.cellimm.2012.06.006.
APA：
Guo, Xuming,Jie, Ying,Ren, Dong,Zeng, Hui,Zhang, Yingnan...&Pan, Zhiqiang.(2012).Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells.CELLULAR IMMUNOLOGY,277,(1-2)
MLA：
Guo, Xuming,et al."Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells".CELLULAR IMMUNOLOGY 277..1-2(2012):8-13
