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The effect of ginkgo biloba on the rat retinal ganglion cell survival in the optic nerve crush model

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机构: [1]Capital Med Univ, Beijing TongRen Eye Hosp, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China
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关键词: ginkgo biloba neuroprotection optic nerve crush retinal ganglion cells

摘要:
Purpose: To investigate the effect of ginkgo biloba on the retinal ganglion cell survival in a rat optic nerve crush model. Methods: Twenty-four Sprague-Dawley rats were divided randomly into a study group of 12 animals receiving intraperitoneal injections of ginkgo biloba and a control group of 12 animals receiving intraperitoneal saline injections. All injections were performed 1 hr before the optic nerve crush and daily afterwards. For each animal, the right optic nerve was crushed closely behind the globe for 60 seconds using a microclip with 40 g power. The left optic nerve was kept intact. At 23 days after the optic nerve crush, the retinal ganglion cells were labelled retrogradely by injecting 3% fluorogold into both sides of the superior colliculus of the brain. At 4 weeks after the optic nerve crush, the animals were killed. Photographs taken from retinal flat mounts were assessed for the number and density of the retinal ganglion cells. Results: The survival rate, defined as the ratio of the retinal ganglion cell density in the right eye with the optic nerve crush divided by the retinal ganglion cell density in left eye without an optic nerve trauma, was significantly (p = 0.035) higher in the study group with ginkgo biloba than in the control group (60.0 +/- 6.0% versus 53.5 +/- 8.0%). Conclusion: The results suggest that intraperitoneal injections of a ginkgo biloba extract given prior to and daily after an experimental and standardized optic nerve crush in rats were associated with a higher survival rate of retinal ganglion cells.

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出版当年[2009]版:
大类 | 3 区 医学
小类 | 3 区 眼科学
最新[2025]版:
大类 | 3 区 医学
小类 | 2 区 眼科学
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出版当年[2008]版:
Q2 OPHTHALMOLOGY
最新[2023]版:
Q1 OPHTHALMOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

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第一作者机构: [1]Capital Med Univ, Beijing TongRen Eye Hosp, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China [*1]Capital Med Univ, Beijing TongRen Eye Hosp, Beijing Inst Ophthalmol, Houguo Lane 17,Chong Nei St, Beijing 100005, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing TongRen Eye Hosp, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China [*1]Capital Med Univ, Beijing TongRen Eye Hosp, Beijing Inst Ophthalmol, Houguo Lane 17,Chong Nei St, Beijing 100005, Peoples R China
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