Background: We studied the association of C-reactive protein (CRP). gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese. Method: A population-based cross-sectional study. Results: CRP and GGT levels were significantly higher in participants with diabetes than in those without (P<0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend=0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend = 0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend <0.001). Conclusion: CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people. Crown Copyright (c) 2009 Published by Elsevier B.V. All rights reserved.
基金：
This study was financially supported by the
National Basic Research Program of China (973 Program), the Ministry
of Science and Technology of China (Grant 2007CB512201), and The
Handan Bureau of Science & Technology. Additional support was
provided by the Foundation of Beijing Tongren Hospital (Grant 2005).
第一作者机构：[1]Capital Med Unv, Beijing Tongren Hosp, Dept Lab Med, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[2]Capital Med Unv, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China[*1]Capital Med Unv, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, 1 DongjiaoMinXiang, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Wen Jiangping,Liang Yuanbo,Wang Fenghua,et al.C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population[J].CLINICA CHIMICA ACTA.2010,411(3-4):198-203.doi:10.1016/j.cca.2009.11.002.
APA：
Wen, Jiangping,Liang, Yuanbo,Wang, Fenghua,Sun, Lanping,Guo, Yongjun...&Wang, Ningli.(2010).C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.CLINICA CHIMICA ACTA,411,(3-4)
MLA：
Wen, Jiangping,et al."C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population".CLINICA CHIMICA ACTA 411..3-4(2010):198-203
