It was shown that the expression of HIF-1 alpha in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1 alpha reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1 alpha decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1 alpha in RPE. It can be an important step in choriodal neovascularization.
基金：
This work was supported by research grantsfrom The National Natural Science Foundation ofChina (10472005) and Natural Science Foundationof Beijing (3052009).
第一作者机构：[1]Univ Technol Beijing, Biomech & Med Informat, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yapjun Zeng,Guangyu Li,Bin Fan,et al.Study of hypoxia-induced expression of HIF-1 alpha in retina pigment epithelium[J].BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE.2007,143(3):323-327.doi:10.1007/s10517-007-0101-3.
APA：
Yapjun, Zeng,Guangyu, Li,Bin, Fan,Qing, Wang,Ying, Jie&Aizhen, Liu.(2007).Study of hypoxia-induced expression of HIF-1 alpha in retina pigment epithelium.BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE,143,(3)
MLA：
Yapjun, Zeng,et al."Study of hypoxia-induced expression of HIF-1 alpha in retina pigment epithelium".BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 143..3(2007):323-327
