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Pharmacokinetics of terbinafine in the rabbit ocular tissues after topical administration

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Ocular Microbiology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital,Capital University of Medical Sciences, Beijing , China

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关键词： antifungal agents terbinafine pharmacokinetics fungal keratitis rabbit

摘要：

Objective: To determine the distribution of terbinafine in the cornea and aqueous humor after topical administration. Methods: A corn oil ointment of terbinafine 0.2% (resolved in sterile corn oil) was applied to the conjunctival sac of albino rabbits twice (with a 5-min interval). The concentration of terbinafine was determined with high-performance liquid chromatography (HPLC) 5, 15, 30, 60, 120 and 240 min after administration of terbinafine. Results: After topical administration, the concentration of terbinafine increased gradually, reached a peak (1.39 mu g/ml at 30 min in the cornea and 82.9 ng/ml at 30 min in aqueous humor, respectively) and then decreased. The concentration was 0.18 mu g/g at 240 min in the cornea, but terbinafine could not be tested at 120 min in aqueous humor. Conclusions: Topical ophthalmic terbinafine 0.2% could penetrate into the cornea and aqueous humor at concentrations adequate for inhibition of fungus. Copyright (c) 2007 S. Karger AG, Basel.

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出版当年[2006]版：

大类 | 4 区医学

最新[2025]版：

大类 | 4 区医学

小类 | 3 区眼科学

JCR分区：

出版当年[2005]版：

Q3 OPHTHALMOLOGY

最新[2023]版：

Q2 OPHTHALMOLOGY

影响因子： 2 最新[2023版] 2.1 最新五年平均 0.874 出版当年[2005版] 0 出版当年五年平均 1 出版前一年[2004版] 1.01 出版后一年[2006版]

第一作者：

第一作者机构： [1]Department of Ocular Microbiology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital,Capital University of Medical Sciences, Beijing , China [*1]Beijing Institute of Ophthalmology, Room 405 17 Hou Gou Lane, Chong Nei Street Beijing 100005 (China)

通讯作者：

通讯机构： [1]Department of Ocular Microbiology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital,Capital University of Medical Sciences, Beijing , China [*1]Beijing Institute of Ophthalmology, Room 405 17 Hou Gou Lane, Chong Nei Street Beijing 100005 (China)

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