机构：[1]Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China[2]Department of Orthopedic Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200336, PR China[3]Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China
Aim:To deliver syringic acid (SA) with a nanocarrier and enhance its function.Materials & methods:mPEG-PLGA-PLL (PEAL) nanoparticles were used to deliver SA. The characterization, storage stability, drug release, blood-compatibility and biocompatibility of SA-PEAL were detected byin vitroandin vivoassays. Cellular phenotypic experiments and rat sciatic nerve injury models were used to evaluate the function of SA-PEALs.Results:SA-PEAL had good storage stability, blood-compatibility and biocompatibility and could slowly release SA. SA-PEAL significantly enhanced the proliferation and migration ability of Schwann cells and function recovery of injured sciatic nerves.Conclusion:Our study provides an effective nano-delivery system for enhancing the neural repair function of SA and promoting further applications of SA.
基金：
National Natural Science Foundation of China (NSFC) [81772327]; Program of Outstanding Medical Talent of Shanghai Municipal Health Bureau [2017BR034]
