Background: The diagnosis and treatment of nonallergic rhinitis with eosinophilia syndrome (NARES) remain controversial. The aim of this study was to evaluate whether Cystatin SN together with symptoms can be used to diagnose NARES and to measure the efficiency of medical treatment. Methods: Seventy-five patients with chronic rhinitis (CR) and 18 control subjects were enrolled. Their clinical characteristics were reviewed and laboratory parameters were evaluated. The concentration of Cystatin SN in nasal secretions was determined using the enzyme-linked immunosorbent assay. The histological assessment of Cystatin SN in the nasal mucosa was conducted by hematoxylin and eosin staining. The logistic regression and receiver operating characteristic curves were used to assess the predictive value of parameters for NARES. Results: Nasal obstruction, sneezing, loss of smell, and total visual analogue scale (VAS) score were significantly different among the patients with CR. In particular, olfaction score was higher in patients with NARES than in those without NARES (AR, LAR, or IR). Similarly, the Cystatin SN level was significantly different between the control subjects and patients with CR. After treatment for 2 weeks, the Cystatin SN level and VAS score were significantly decreased in the NARES group. The accuracy of Cystatin SN together with local sIgE and loss of smell to diagnose NARES was up to 0.987 (sensitivity, 100%; specificity, 93.1%). Conclusions: Cystatin SN with local sIgE and loss of smell may serve as one of the reliable and alternative biomarkers for the diagnosis of NARES and be used to evaluate disease severity and NARES treatment efficacy.
基金：
National Natural Science Foundation of China (81900916), Beijing
Municipal Administration of Hospitals’ Youth Programme
(QML20190208), the Priming Scientific Research
Foundation for the Senior Researcher in Beijing TongRen
Hospital, Capital Medical University (2017-YJJ-GGL-005),
National Key R&D Program of China (2018YFC0116800),
the program for Changjiang Scholars and Innovative
Research Team (IRT13082), Beijing Scientific and
Technological Overall Plan (Z171100000117002), Beijing
Municipal Administration of Hospitals Clinical Medicine
Development of Special Funding Support (XMLX201816),
Beijing Natural Science Foundation (7194247), Public
Welfare Development and Reform Pilot Project (2019-10),
and Beijing Municipal Administration of Hospitals
incubating Program (PX20190007).
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing 100005, Peoples R China[3]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing 100730, Peoples R China[*1]Beijing Inst Otolaryngol, 17 HouGouHuTong, Beijing 100005, Peoples R China[*2]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Meng Yifan,Yan Bing,Wang Yang,et al.Diagnosis and management of nonallergic rhinitis with eosinophilia syndrome using cystatin SN together with symptoms[J].WORLD ALLERGY ORGANIZATION JOURNAL.2020,13(7):doi:10.1016/j.waojou.2020.100134.
APA：
Meng, Yifan,Yan, Bing,Wang, Yang,Wu, Di,Zhang, Luo&Wang, Chengshuo.(2020).Diagnosis and management of nonallergic rhinitis with eosinophilia syndrome using cystatin SN together with symptoms.WORLD ALLERGY ORGANIZATION JOURNAL,13,(7)
MLA：
Meng, Yifan,et al."Diagnosis and management of nonallergic rhinitis with eosinophilia syndrome using cystatin SN together with symptoms".WORLD ALLERGY ORGANIZATION JOURNAL 13..7(2020)
