Diabetic nephropathy (DN) as one of the most frequent microvascular complications of diabetic patients causes chronic renal failure and end-stage renal disease. Noncoding RNAs including circular RNAs (circRNAs) and micro RNAs (miRNAs) were widely reported to play a critical role in numerous human diseases including DN. This research was designed to investigate the role of circ_0000064 in diabetic nephropathy progression. The results showed that circ_0000064 significantly promoted mesangial cells proliferation and aggravated fibrosis in DN. In the subsequent mechanism investigation, we found that circ_0000064 was involved in this process by targeting micro RNA miR-143. The inhibition of miR-143 significantly reverses the effect of circ_0000064 silencing on DN. In conclusion, we demonstrated the regulatory role of circ_0000064 in DN and clarified that circ_0000064 play a role in DN via targeting miR-143. Circ_0000064 and miR-143 also showed the potential as a biomarker for DN.
基金：
Key Program of Science and Technology Committee of Changning District (Shanghai, China) [CNKW2016Z03]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81800715]
第一作者机构：[1]Jiaotong Univ, Dept Endocrinol, Tongren Hosp, Shanghai, Peoples R China
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推荐引用方式(GB/T 7714)：
Ge Xiaoxu,Xi Liuqing,Wang Qianqian,et al.Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy[J].GENE.2020,758:doi:10.1016/j.gene.2020.144952.
APA：
Ge, Xiaoxu,Xi, Liuqing,Wang, Qianqian,Li, Huihua,Xia, Lili...&Huang, Shan.(2020).Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy.GENE,758,
MLA：
Ge, Xiaoxu,et al."Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy".GENE 758.(2020)
