机构：[1]Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin, China.[2]Department of Ophthalmology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Tianjin, 300052, China.[3]Department of Ophthalmology, Peking University Third Hospital, Beijing, China.[4]Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin, China.[5]Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.[6]Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS, 39216, USA.[7]Department of Ophthalmology and Visual Sciences, Federal University of São Paulo, São Paulo, 04023-062, Brazil
There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamethasone prophylactically at the end of intraocular surgery.This was a retrospective cohort study of patients who received intraocular surgery at Tianjin Medical University General Hospital from January 2015 to December 2017. The patients were grouped according to whether they received tobramycin-dexamethasone eye ointment or not after surgery. The Tobramycin dexamethasone eye ointment was sampled to observe bacterial contamination pathogens at 0.5, 1, 1.5, 2, 2.5, 3, 6, 8, 24, 36, 48, 72, and 168 h after being opened.A total of 3811 eyes in 3811 patients (mean age of 63 ± 12 years) were included: 2397 eyes that received prophylactic tobramycin-dexamethasone eye ointment and 1414 eyes that did not. The overall rate of endophthalmitis was 0.08% (3/3811) in our study, all in the eye ointment group (0.12%, 3/2397); no patients developed endophthalmitis in the non-ointment group (0%, 0/1414)(P = 0.184). The anterior chamber reactions 1 day after surgery were more serious in the eye ointment group compared with the non-ointment group (all P < 0.05), but there were no statistically significant differences at 1 month postoperatively (all P > 0.05). The contamination rate was 0% at all time points over 7 days.We did not observe a statistically significant difference in the incidence of endophthalmitis in patients with or without prophylactic tobramycin-dexamethasone eye ointment. And tobramycin-dexamethasone eye ointment seemed to increase some side effects such as eye secretions increasing and foreign body feeling.
基金：
National Natural Science Foundation of
China (grant numbers 81830026 for Hua Yan, 31871184 for Xiaohong Wang,
81800815 for Xiangda Meng) and the Natural Science Foundation of Tianjin
(grant number 18ZXDBSY00030 for Hua Yan).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区眼科学
最新[2023]版：
大类|4 区医学
小类|3 区眼科学
第一作者：
第一作者机构：[1]Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Ophthalmology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Tianjin, 300052, China.[4]Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin, China.
推荐引用方式(GB/T 7714)：
Zhang Wei,Han Han,Feng Kang,et al.Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery?[J].BMC ophthalmology.2020,20(1):208.doi:10.1186/s12886-020-01476-z.
APA：
Zhang Wei,Han Han,Feng Kang,Wang Xiaohong,Du Mei...&Yan Hua.(2020).Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery?.BMC ophthalmology,20,(1)
MLA：
Zhang Wei,et al."Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery?".BMC ophthalmology 20..1(2020):208
