机构：[1]Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing 100096, China.[2]Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.[3]Department of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, Sichuan 618000, China.[4]Department of Neurology, Shanghai Tongren Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.[5]Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
Putamen is enriched with dopamine and associated with dopamine-related phenotypes including many neuropsychiatric and neurodegenerative disorders that manifest with motor impairment, impulsive behavior, and cognitive deficits. The gray matter volume of the putamen is age-dependent and genetically controlled. In most neuropsychiatric and neurodegenerative disorders, including Parkinson's spectrum disorders, Huntington's disease, dementia with Lewy bodies, Alzheimer's disease, multiple sclerosis, attention deficit hyperactivity disorder, developmental dyslexia, and major depression, the putamen volume is significantly reduced. On the other hand, in individuals with bipolar disorder, schizophrenia spectrum disorders, especially neuroleptics-medicated patients with schizophrenia, autism spectrum disorders, obsessive-compulsive spectrum disorders, and cocaine/amphetamine dependence, the putamen volume is significantly enlarged. Therefore, the putamen volume may serve as a structural neural marker for many neuropsychiatric and neurodegenerative disorders and a predictor of treatment outcomes in individuals afflicted with these conditions. We provided an overview of the genetic bases of putamen volume and explored potential mechanisms whereby altered putamen volume manifests in these neuropsychiatric and neurodegenerative conditions, with a specific focus on dopaminergic processes.
基金：
NIH grants R21AA021380,
R21AA020319 and R21AA023237 (XL), and DA023248 (CRL).
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing 100096, China.[2]Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.[*1]Department of Psychiatry, Yale University School of Medicine, Biological Psychiatry Research Center, Beijing Huilongguan Hospital, New Haven, CT 06520, USA
通讯作者：
通讯机构：[1]Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing 100096, China.[2]Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.[5]Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA[*1]Department of Psychiatry, Yale University School of Medicine, Biological Psychiatry Research Center, Beijing Huilongguan Hospital, New Haven, CT 06520, USA[*2]Department of Psychiatry and Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA
推荐引用方式(GB/T 7714)：
Luo Xingguang,Mao Qiao,Shi Jing,et al.Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.[J].World journal of psychiatry and mental health research.2019,3(1):
APA：
Luo Xingguang,Mao Qiao,Shi Jing,Wang Xiaoping&Li Chiang-Shan R.(2019).Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders..World journal of psychiatry and mental health research,3,(1)
MLA：
Luo Xingguang,et al."Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.".World journal of psychiatry and mental health research 3..1(2019)
