机构：[1]Department of Radiology, Shanghai NinthPeople’s Hospital, Shanghai Jiao Tong UniversitySchool of Medicine, Shanghai, People’s Republic ofChina[2]Department of Radiology, Shanghai JiaoTong University Affiliated Sixth People’s Hospital,Shanghai, People’s Republic of China[3]Department of Pathology, Shanghai Jiao TongUniversity Affiliated Sixth People’s Hospital,Shanghai, People’s Republic of China[4]Department of Orthopaedics, Shanghai Jiao TongUniversity Affiliated Sixth People’s Hospital,Shanghai, People’s Republic of China[5]KeyLaboratory of Carcinogenesis and TranslationalResearch (Ministry of Education), Department ofHead and Neck Surgery, Peking UniversityCancer Hospital & Institute, Beijing, People’sRepublic of China[6]Department ofOtorhinolaryngology, Union Hospital, TongjiMedical College, Huazhong University of Scienceand Technology, Wuhan, People’s Republic ofChina华中科技大学同济医学院附属协和医院[7]Department of Radiology, ShanghaiTongren Hospital, Shanghai JiaoTong UniversitySchool of Medicine, Shanghai, People’s Republic ofChina
Background: Dedifferentiated chondrosarcoma (DC) is an extremely uncommon malignant bone tumor with dismal survival outcomes. The purpose of this study was to investigate whether the preoperative neutrophil/lymphocyte ratio (NLR) has the ability to predict overall survival (OS) in DC patients. Materials and Methods: Twenty-three DC patients with surgical resection were retrospectively reviewed between 2008 and 2015. The clinical pathological information and survival data were collected for analysis. The cut-off point for NLR was defined by receiver operating curve (ROC). The impact of NLR level on OS between two groups was compared using Kaplan-Meier curves with the Log-rank test. The association between NLR and OS was calculated by univariate and multivariate Cox proportional models. Results: From the ROC analysis, the optimal NLR cut-off point was 3.11. Patients with high NLR had a worse OS than low NLR (p = 0.003, Log-rank test). In univariate analysis, a significant association was observed between high NLR and poor OS (Hazard ratio (HR) 4.62, 95% confidence interval (CI) 1.48-14.34, p = 0.008). After adjustment of co-variables, high NLR had more than 4 times the risk of mortality (HR 4.01, 95% CI 1.12-14.26, p = 0.032). Conclusion: Preoperative NLR in peripheral blood is an easily accessible and cost-effective prognostic biomarker in DC patients. A prospective study with large sample size is warranted.
基金：
National Natural Science
Foundation of China (No. 81771790), and Shanghai
Scientific Research Plan Project (No.16511101101).
第一作者机构：[1]Department of Radiology, Shanghai NinthPeople’s Hospital, Shanghai Jiao Tong UniversitySchool of Medicine, Shanghai, People’s Republic ofChina
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, Shanghai NinthPeople’s Hospital, Shanghai Jiao Tong UniversitySchool of Medicine, Shanghai, People’s Republic ofChina[7]Department of Radiology, ShanghaiTongren Hospital, Shanghai JiaoTong UniversitySchool of Medicine, Shanghai, People’s Republic ofChina[*1]Department of Radiology, Shanghai Tongren Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China[*2]Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
推荐引用方式(GB/T 7714)：
Liu Chenglei,Xing Yue,Jiao Qiong,et al.Association of Preoperative Neutrophil/Lymphocyte Ratio with Clinical Outcomes in Dedifferentiated Chondrosarcoma Patients[J].CANCER MANAGEMENT AND RESEARCH.2020,12:6719-6726.doi:10.2147/CMAR.S266671.
APA：
Liu, Chenglei,Xing, Yue,Jiao, Qiong,Yang, Qingcheng,Yu, Wenbin...&Yao, Weiwu.(2020).Association of Preoperative Neutrophil/Lymphocyte Ratio with Clinical Outcomes in Dedifferentiated Chondrosarcoma Patients.CANCER MANAGEMENT AND RESEARCH,12,
MLA：
Liu, Chenglei,et al."Association of Preoperative Neutrophil/Lymphocyte Ratio with Clinical Outcomes in Dedifferentiated Chondrosarcoma Patients".CANCER MANAGEMENT AND RESEARCH 12.(2020):6719-6726
