机构：[1]Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria[2]Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland[3]CK CARE, Christine Kühne Center for Allergy Research and Education, Davos, Switzerland[4]Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China中山大学附属第一医院[5]Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania[6]Department of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden[7]Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic[8]Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands[9]Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada[10]Department of Immunology, University of Toronto, Toronto, ON, Canada[11]Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON, Canada[12]Department of Otorhinolaryngology, Amsterdam University Medical Centres, Amsterdam, The Netherlands[13]Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany[14]ZIEL - Institute for Food & Health, Technical University of Munich, Freising-Weihenstephan, Germany[15]Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA[16]Department of Allergy, immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Vic., Australia[17]Allergy, Asthma and Clinical Immunology Service, Alfred Health, Melbourne, Vic., Australia[18]Departments of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland[19]Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany[20]Allergy Unit, Regional University Hospital of Malaga-IBIMA-UMA-ARADyAL, Malaga, Spain[21]Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore[22]Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing TongRen Hospital, Beijing, China临床科室耳鼻咽喉-头颈外科变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.
第一作者机构：[1]Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria[*1]Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
通讯作者：
通讯机构：[1]Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria[*1]Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
推荐引用方式(GB/T 7714)：
Breiteneder Heimo,Peng Ya Qi,Agache Ioana,et al.Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma[J].ALLERGY.2020,75(12):3039-3068.doi:10.1111/all.14582.
APA：
Breiteneder, Heimo,Peng, Ya Qi,Agache, Ioana,Diamant, Zuzana,Eiwegger, Thomas...&Akdis, Cezmi A..(2020).Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.ALLERGY,75,(12)
MLA：
Breiteneder, Heimo,et al."Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma".ALLERGY 75..12(2020):3039-3068
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