Candidain Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study
Objective:To explore impact ofCandidaon the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) outcome. Methods:A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011-Dec 2016 were enrolled. Data were collected, including demographic information, conditions during the stable phase of COPD, clinical characteristics of AECOPD, and follow-up information within 1 year after discharge. Univariate analysis and binary logistic regression were applied, andp< 0.05 was regarded as significant. Results:Totally 1,103 patients were analyzed, with 644 lower respiratory airway (LTR)Candidapositive cases and 459Candidanegative controls. Long-term prognosis was significantly different betweenCandidapositive and negative group, including the recurrent AECOPD within 180 days (75.5 vs. 6.6%,p< 0.001) and mortality within 1 year (6.9 vs. 0.4%,p< 0.001). Univariate logistic analysis showed that LTRCandidaisolation was related to higher recurrence rate of AECOPD within 180 days and mortality within 1 year. Binary logistic regression analysis demonstrated that LTRCandidaisolation was independently associated with recurrence of AECOPD within 180 days. Conclusions:LTRCandidaisolation was associated with worse long-term prognosis of AECOPD and independently related to higher risks of recurrent AECOPD within 180 days.
基金：
National Key Research and
Development Program of China (grant no. 2017YFC1309300)
and National Innovative Research Team of High-level Local
Universities in Shanghai and the Shanghai Top-Priority Clinical
Key Disciplines Construction Project (2017ZZ02013).
第一作者机构：[1]Fudan Univ, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zuo Yi-hui,Wang Wei-qin,Chen Qi-jian,et al.Candidain Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study[J].FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.2020,10:doi:10.3389/fcimb.2020.538005.
APA：
Zuo, Yi-hui,Wang, Wei-qin,Chen, Qi-jian,Liu, Bin,Zhang, Feng-ying...&on behalf of CAN-CRD study group.(2020).Candidain Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,10,
MLA：
Zuo, Yi-hui,et al."Candidain Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 10.(2020)
