机构：[1]Department of Urology, Institute of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020北京朝阳医院[2]Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730临床科室泌尿外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China
Ribosome-binding protein 1 (RRBP1) is a marker for colorectal, lung, esophageal and prostate cancer. However, the association between RRBP1 and bladder cancer is not completely understood. The present study aimed to evaluate the expression and function of RRBP1 in bladder cancer. The association between RRBP1 expression and clinicopathological characteristics, as well as the prognosis of bladder cancer was analyzed. RRBP1 expression was further analyzed in bladder cancer cell lines via reverse transcription-quantitative PCR and western blotting. RRBP1 knockdown was established using short hairpin RNAs to investigate the function of RRBP1 in T24 cells. Compared with healthy bladder tissue, RRBP1 expression levels were significantly upregulated in bladder cancer tissue. High RRBP1 expression was associated with tumor stage, lymph node metastasis and shorter overall survival time. RRBP1 protein was highly expressed in bladder cancer cell lines compared with normal SV-HUC-1 cells. Compared with the control group, RRBP1 knockdown inhibited T24 migration and invasion by downregulating the expression of C-C chemokine receptor type 7 (CCR7) protein. In conclusion, the present study indicated that RRBP1 was associated with bladder cancer migration, invasion and prognosis, and CCR7 might serve a role in the process.
基金：
The present study was supported by the National Natural Science Foundation of China (grant no. 81772700) and the Beijing Natural Science Foundation (grant no. 7194271).
第一作者机构：[1]Department of Urology, Institute of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020
通讯作者：
通讯机构：[2]Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730[3]Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China[*1]Department of Urology, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiao Mingang, Dongcheng, Beijing 100730, P.R. China[*2]Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Beijing Hua Wei South Road, Pan Jia Yuan Nan Li Block, Beijing 100021, P.R. China
推荐引用方式(GB/T 7714)：
Wang Mingshuai,Liu Sai,Zhou Bolin,et al.RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion[J].ONCOLOGY LETTERS.2020,20(5):doi:10.3892/ol.2020.12066.
APA：
Wang, Mingshuai,Liu, Sai,Zhou, Bolin,Wang, Jianwen,Ping, Hao&Xing, Nianzeng.(2020).RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion.ONCOLOGY LETTERS,20,(5)
MLA：
Wang, Mingshuai,et al."RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion".ONCOLOGY LETTERS 20..5(2020)
