机构：[1]Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai, China,[2]Department of Rheumatology and Immunology, The First People’s Hospital of Yancheng, The Forth Affiliated Hospital of Nantong University, Yancheng, China,[3]Department of Rheumatology and Immunology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China,[4]Department of Endocrinology, The Second AffiliatedHospital of Anhui Medical University, Hefei, China,[5]Shanghai Tongren Hospital/Clinical Research Institute, HongqiaoInternational Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[6]Shanghai Clinical Research Promotion and Development Center, Shanghai Shenkang Hospital Development Center, Shanghai, China,[7]The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China
Objective: Adult-onset Still's disease (AOSD) is a systemic disorder commonly accompanied by liver involvement. This study aims to illustrate the detailed information of liver abnormalities in patients with AOSD and evaluate the impact on the prognosis. Methods: A total number of 128 hospitalized patients, who met the Yamaguchi criteria of AOSD in the Department of Rheumatology and Immunology, Ruijin Hospital from July 2016 to August 2019 were consecutively enrolled and followed up. The demographic characteristics, clinical features, laboratory tests, treatments and prognosis were recorded. Correlations of liver function tests (LFTs) with disease activity and laboratory parameters were analyzed by the Spearman test. Risk factors of the refractory AOSD were evaluated by multivariate logistic regression analysis. Results: Liver involvement was presented in 104 (81.3%) patients with AOSD. We observed that 34 (32.7%) patients were with mild elevation, 32 (30.8%) patients were with moderate elevation, and 38 (36.5%) patients were with severe elevation. The majority of elevated ALT, AST and ALP decreased to normal within the range of 2 months, except for GGT. Furthermore, the LFTs were found significantly correlated with disease activity. Besides, we found patients with higher levels of LFTs tended to require more intensive treatments and suffered from poorer prognosis. Multivariate logistic regression analysis showed ALP >= 141 IU/L and GGT >= 132 IU/L are independent risk factors of refractory AOSD. Conclusion: Liver involvement is common in patients with AOSD, the levels of LFTs are associated with disease activity and related to the treatment strategies and prognosis.
基金：
National Natural Science
Foundation of China [81801600], the Shanghai Sailing
Program [18YF1414500], and Shanghai Science and Technology
Innovation Action [20Y11911500].
第一作者机构：[1]Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chi Huihui,Wang Zhihong,Meng Jianfen,et al.A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis[J].FRONTIERS IN MEDICINE.2020,7:doi:10.3389/fmed.2020.621005.
APA：
Chi, Huihui,Wang, Zhihong,Meng, Jianfen,Han, Pingyang,Zhai, Limin...&Su, Yutong.(2020).A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis.FRONTIERS IN MEDICINE,7,
MLA：
Chi, Huihui,et al."A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis".FRONTIERS IN MEDICINE 7.(2020)
