机构：[1]Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan, China,华中科技大学同济医学院附属协和医院[2]Department of Otolaryngology Head and Neck, Nanjing Tongren Hospital, Schoolof Medicine, Southeast University, Nanjing, China,[3]State Key Laboratory of Bioelectronics, School of Life Sciencesand Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing,China,[4]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China,[5]Institute of Stem Celland Regeneration, Chinese Academy of Sciences, Beijing, China,[6]Beijing Key Laboratory of Neural Regenerationand Repair, Capital Medical University, Beijing, China
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem. When the inner ear is abnormally developed or is damaged by inflammation, ototoxic drugs, or blood supply disorders, auditory signal transmission is inhibited resulting in hearing loss. Forkhead box G1 (FoxG1) is an important nuclear transcriptional regulator, which is related to the differentiation, proliferation, development, and survival of cells in the brain, telencephalon, inner ear, and other tissues. Previous studies have shown that when FoxG1 is abnormally expressed, the development and function of inner ear hair cells is impaired. This review discusses the role and regulatory mechanism of FoxG1 in inner ear tissue from various aspects - such as the effect on inner ear development, the maintenance of inner ear structure and function, and its role in the inner ear when subjected to various stimulations or injuries - in order to explain the potential significance of FoxG1 as a new target for the treatment of hearing loss.
基金：
Strategic
Priority Research Program of the Chinese Academy
of Sciences (XDA16010303), National Natural Science
Foundation of China (Nos. 81873700, 81800915, 82030029,
and 81970882), National Key R&D Program of China
(Nos. 2017YFA0103903 and 2019YFA0111400), Natural
Science Foundation of Jiangsu Province (BE2019711), and
Shenzhen Fundamental Research Program (JCYJ2019081
4093401920).
第一作者机构：[1]Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan, China,
通讯作者：
通讯机构：[3]State Key Laboratory of Bioelectronics, School of Life Sciencesand Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing,China,[4]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China,[5]Institute of Stem Celland Regeneration, Chinese Academy of Sciences, Beijing, China,[6]Beijing Key Laboratory of Neural Regenerationand Repair, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Ding Yanyan,Meng Wei,Kong Weijia,et al.The Role of FoxG1 in the Inner Ear[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2020,8:doi:10.3389/fcell.2020.614954.
APA：
Ding, Yanyan,Meng, Wei,Kong, Weijia,He, Zuhong&Chai, Renjie.(2020).The Role of FoxG1 in the Inner Ear.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8,
MLA：
Ding, Yanyan,et al."The Role of FoxG1 in the Inner Ear".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8.(2020)
